Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | aspartyl protease ASP3 | 0.0707 | 0.4532 | 1 |
Plasmodium falciparum | plasmepsin IX | 0.0707 | 0.4532 | 1 |
Plasmodium vivax | aspartyl protease, putative | 0.0707 | 0.4532 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0256 | 0.0256 | 0.0256 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.1257 | 0.9738 | 0.9738 |
Plasmodium vivax | aspartyl protease, putative | 0.0707 | 0.4532 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0256 | 0.0256 | 0.5 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0256 | 0.0256 | 0.5 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0256 | 0.0256 | 0.5 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0256 | 0.0256 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.1285 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.0256 | 0.5 |
Plasmodium falciparum | plasmepsin X | 0.0707 | 0.4532 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of [3H]-glycine binding to glycine site of N-methyl-D-aspartate glutamate receptor in rat cortical membranes | ChEMBL. | 1826744 |
IC50 (binding) | > 100 uM | Inhibition of [3H]-glycine binding to glycine site of N-methyl-D-aspartate glutamate receptor in rat cortical membranes | ChEMBL. | 1826744 |
Kb (binding) | > 300 uM | Apparent dissociation constant of [3H]-glycine from N-methyl-D-aspartate glutamate receptor in rat cortical slice preparation | ChEMBL. | 1826744 |
Kb (binding) | > 300 uM | Apparent dissociation constant of [3H]-glycine from N-methyl-D-aspartate glutamate receptor in rat cortical slice preparation | ChEMBL. | 1826744 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.