Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1111 | 0.2248 | 0.8788 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.2422 | 0.5005 | 0.4983 |
Echinococcus granulosus | carbonic anhydrase | 0.2422 | 0.5005 | 0.5005 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0045 | 0.0009 | 0.0009 |
Schistosoma mansoni | carbonic anhydrase-related | 0.2422 | 0.5005 | 0.5001 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4798 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.2422 | 0.5005 | 0.5005 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.4798 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.4798 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.4798 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4798 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.2422 | 0.5005 | 0.5005 |
Loa Loa (eye worm) | hypothetical protein | 0.2422 | 0.5005 | 0.4983 |
Entamoeba histolytica | protein kinase, putative | 0.0066 | 0.0052 | 0.0138 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2422 | 0.5005 | 0.4983 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0066 | 0.0052 | 0.0009 |
Echinococcus granulosus | carbonic anhydrase II | 0.4798 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1778 | 0.3652 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1839 | 0.378 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.2422 | 0.5005 | 0.5001 |
Giardia lamblia | Kinase, AGC PKA | 0.0041 | 0 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.2422 | 0.5005 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4798 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1778 | 0.3652 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0062 | 0.0043 | 0.0115 |
Schistosoma mansoni | carbonic anhydrase | 0.1839 | 0.378 | 0.3775 |
Echinococcus multilocularis | carbonic anhydrase | 0.2422 | 0.5005 | 0.5005 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.4798 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2422 | 0.5005 | 0.4983 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0045 | 0.0009 | 0.0009 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1839 | 0.378 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4798 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0066 | 0.0052 | 0.0138 |
Echinococcus multilocularis | carbonic anhydrase | 0.2422 | 0.5005 | 0.5005 |
Toxoplasma gondii | hypothetical protein | 0.2422 | 0.5005 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.4798 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0066 | 0.0052 | 0.0009 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0045 | 0.0009 | 0.0009 |
Schistosoma mansoni | hypothetical protein | 0.2422 | 0.5005 | 0.5001 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.1172 | 0.2377 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2422 | 0.5005 | 0.4983 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0041 | 0 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1839 | 0.378 | 0.5 |
Trypanosoma cruzi | Protein kinase B | 0.0045 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.3097 | 0.6424 | 0.6409 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2422 | 0.5005 | 0.4983 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0045 | 0.0009 | 0.0023 |
Schistosoma mansoni | carbonic anhydrase | 0.2422 | 0.5005 | 0.5001 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.2422 | 0.5005 | 0.4983 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2422 | 0.5005 | 0.4983 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.4798 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.2422 | 0.5005 | 0.5001 |
Echinococcus granulosus | carbonic anhydrase | 0.2422 | 0.5005 | 0.5005 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0045 | 0.0009 | 0.0023 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (functional) | = 1.1 | The P-glycoprotein (Pgp) antagonism score is the percentage of NCI/ADR cells surviving in the absence of vinblastine to that of in the presence of vinblastine. | ChEMBL. | 11170649 |
Ratio (functional) | = 2.1 | The MRP1 antagonism score is the percentage of MCF-7/VP cells surviving in the absence of vincristine to that of in the presence of vincristine. | ChEMBL. | 11170649 |
Ratio (functional) | = 0.5 | Ratio for antagonistic activity for Pgp/MRP1 was determined | ChEMBL. | 11170649 |
Ratio (functional) | = 1.1 | The P-glycoprotein (Pgp) antagonism score is the percentage of NCI/ADR cells surviving in the absence of vinblastine to that of in the presence of vinblastine. | ChEMBL. | 11170649 |
Ratio (functional) | = 2.1 | The MRP1 antagonism score is the percentage of MCF-7/VP cells surviving in the absence of vincristine to that of in the presence of vincristine. | ChEMBL. | 11170649 |
Toxicity (functional) | = 3 uM | Toxicity as percentage of MCF-7 cells killed at 10 ug/mL | ChEMBL. | 11170649 |
Toxicity (functional) | = 3 uM | Toxicity as percentage of MCF-7 cells killed at 10 ug/mL | ChEMBL. | 11170649 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.