Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ICD (functional) | = 0 | Induced circular dichroism (ICD), expressed as molar ellipticity, in the presence of calf-thymus DNA | ChEMBL. | 3346875 |
ID50 (functional) | = 20 nM | In vitro concentration required to inhibit 50% growth of murine L1210 leukemia cells | ChEMBL. | 3346875 |
ID50 (functional) | = 20 nM | In vitro concentration required to inhibit 50% growth of murine L1210 leukemia cells | ChEMBL. | 3346875 |
ILS (functional) | = 45 % | In vivo % increase in life span of treated animals (OD) over that of control mice bearing tumor,determined against P388 leukemia cells | ChEMBL. | 3346875 |
ILS (functional) | = 45 % | In vivo % increase in life span of treated animals (OD) over that of control mice bearing tumor,determined against P388 leukemia cells | ChEMBL. | 3346875 |
OD (functional) | = 3 mg kg-1 day-1 | In vivo optimum dose given on days 1, 5, and 9 to mice implanted intraperitoneally with P388 leukemia cells | ChEMBL. | 3346875 |
OD (functional) | = 3 mg kg-1 day-1 | In vivo optimum dose given on days 1, 5, and 9 to mice implanted intraperitoneally with P388 leukemia cells | ChEMBL. | 3346875 |
Rf (ADMET) | = 0.9 | Lipophilic/hydrophilic partitioning (RP-TLC) | ChEMBL. | 3346875 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.