Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0462 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.0909 | 0.1035 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.0909 | 0.1035 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0687 | 0.4947 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0262 | 0.131 | 0.044 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0488 | 0.3243 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0462 | 0.0069 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0488 | 0.3243 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0215 | 0.0909 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0462 | 0.0069 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.1279 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.131 | 0.1899 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0488 | 0.3243 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0215 | 0.0909 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0262 | 0.131 | 0.044 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0701 | 0.5061 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.0909 | 0.1035 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0462 | 0.0069 |
Loa Loa (eye worm) | matrixin family protein | 0.0476 | 0.3145 | 0.5863 |
Brugia malayi | Matrixin family protein | 0.0215 | 0.0909 | 0.0081 |
Onchocerca volvulus | 0.0215 | 0.0909 | 0.0149 | |
Brugia malayi | Matrixin family protein | 0.0426 | 0.2711 | 0.4386 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0462 | 0.0069 |
Mycobacterium ulcerans | peptide deformylase | 0.1279 | 1 | 1 |
Brugia malayi | Peptidase family M13 containing protein | 0.0215 | 0.0909 | 0.0081 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0262 | 0.131 | 0.1037 |
Brugia malayi | Matrixin family protein | 0.0215 | 0.0909 | 0.0081 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0476 | 0.3145 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.0909 | 0.1035 |
Onchocerca volvulus | Matrilysin homolog | 0.0476 | 0.3145 | 1 |
Plasmodium falciparum | peptide deformylase | 0.1279 | 1 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0215 | 0.0909 | 0.0081 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0215 | 0.0909 | 0.1035 |
Loa Loa (eye worm) | matrixin family protein | 0.0426 | 0.2711 | 0.4926 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0687 | 0.4947 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0211 | 0.0876 | 0.9629 |
Brugia malayi | Matrixin family protein | 0.0215 | 0.0909 | 0.0081 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0488 | 0.3243 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.0909 | 0.1035 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0215 | 0.0909 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.1279 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.0909 | 0.1035 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0488 | 0.3243 | 0.5 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0215 | 0.0909 | 0.0081 |
Mycobacterium ulcerans | hydrolase | 0.0262 | 0.131 | 0.044 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0701 | 0.5061 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0488 | 0.3243 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0488 | 0.3243 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0462 | 0.0069 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.1279 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.1279 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1279 | 1 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.1279 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.19 mg kg-1 | In vivo antimuscarinic activity in guinea pig cystometrogram (CMG) model | ChEMBL. | 8496940 |
ED50 (functional) | = 0.19 mg kg-1 | In vivo antimuscarinic activity in guinea pig cystometrogram (CMG) model | ChEMBL. | 8496940 |
ED50 (functional) | = 9.7 mg kg-1 | In vivo antimuscarinic activity evaulated for its liability to cause mydriasis in guinea pig | ChEMBL. | 8496940 |
ED50 (functional) | = 9.7 mg kg-1 | In vivo antimuscarinic activity evaulated for its liability to cause mydriasis in guinea pig | ChEMBL. | 8496940 |
ID50 (functional) | = 0.24 mg kg-1 | In vivo antimuscarinic activity to decrease carbachol-stimulated salivation in guinea pig | ChEMBL. | 8496940 |
ID50 (functional) | = 0.24 mg kg-1 | In vivo antimuscarinic activity to decrease carbachol-stimulated salivation in guinea pig | ChEMBL. | 8496940 |
Kb (functional) | = 2.6 nM | Antagonist activity against muscarinic M3 receptor from guinea pig ileum | ChEMBL. | 8496940 |
Kb (functional) | = 2.6 nM | Antagonist activity against muscarinic M3 receptor from guinea pig ileum | ChEMBL. | 8496940 |
Kb (functional) | = 11 nM | Antagonist activity against muscarinic M1 receptor from rabbit vas deferens | ChEMBL. | 8496940 |
Kb (functional) | = 11 nM | Antagonist activity against muscarinic M1 receptor from rabbit vas deferens | ChEMBL. | 8496940 |
Kb (functional) | = 78 nM | Antagonist activity against muscarinic M2 receptor from guinea pig atria | ChEMBL. | 8496940 |
Kb (functional) | = 78 nM | Antagonist activity against muscarinic M2 receptor from guinea pig atria | ChEMBL. | 8496940 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.