Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Schistosoma mansoni | ATP synthase F0 subunit 6 | Curated by TDR Targets | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0253829 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0253829 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0253829 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0253829 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0253829 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.00879592 | 0.152811 | 0.123389 |
Trichomonas vaginalis | mercuric reductase, putative | 0.00879592 | 0.152811 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0253829 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.0204745 | 0.749299 | 1 |
Leishmania major | trypanothione reductase | 0.0253829 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.00879592 | 0.152811 | 0.5 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) | 0.0204745 | 0.749299 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0253829 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.00879592 | 0.152811 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.00879592 | 0.152811 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0253829 | 1 | 1 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0204745 | 0.749299 | 0.704078 |
Plasmodium falciparum | glutathione reductase | 0.0253829 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0253829 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0253829 | 1 | 1 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0204745 | 0.749299 | 0.704078 |
Trichomonas vaginalis | glutathione reductase, putative | 0.00879592 | 0.152811 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0253829 | 1 | 1 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0204745 | 0.749299 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0253829 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0253829 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.02 uM | Antiparasitic activity against malaria parasite (Plasmodium falciparum D6) | ChEMBL. | 14741254 |
EC50 (functional) | = 0.02 uM | Antiparasitic activity against chloroquine resistant Plasmodium falciparum W2 strain | ChEMBL. | 14741254 |
EC50 (functional) | = 0.02 uM | Antiparasitic activity against malaria parasite (Plasmodium falciparum D6) | ChEMBL. | 14741254 |
EC50 (functional) | = 0.02 uM | Antiparasitic activity against chloroquine resistant Plasmodium falciparum W2 strain | ChEMBL. | 14741254 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 14741254 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
growth (GO:0040007) | lethal (sensu genetics) (PATO:0000718) | multi-cellular organism (CARO:0000012) | bloodstream stage (PLO:0040) | in vivo inhibition (TDR:00016) | Plasmodium falciparum | 3184 |
Annotator: | saralph@unimelb.edu.au | Comment: | 012/Mar/09 | References: | 12931192 15937493 |
31 literature references were collected for this gene.