Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0166 | 0 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0214 | 0.0972 | 0.2965 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0214 | 0.0972 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0302 | 0.2731 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.2102 | 0.2102 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0166 | 0 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0329 | 0.3277 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0972 | 0.0972 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.9458 | 0.9458 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0495 | 0.6603 | 0.6238 |
Loa Loa (eye worm) | matrixin family protein | 0.0329 | 0.3277 | 0.3277 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.0538 | 0.0538 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0193 | 0.0538 | 0.0538 |
Mycobacterium ulcerans | hydrolase | 0.0166 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.0538 | 0.0538 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0664 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.0546 | 0.0008 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0302 | 0.2731 | 0.2731 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0214 | 0.0972 | 0.0972 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0214 | 0.0972 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0302 | 0.2731 | 1 |
Onchocerca volvulus | 0.0193 | 0.0546 | 0.0035 | |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0193 | 0.0538 | 0.1643 |
Brugia malayi | Hemopexin family protein | 0.0193 | 0.0546 | 0.1666 |
Loa Loa (eye worm) | AStacin protease | 0.0415 | 0.5005 | 0.5005 |
Brugia malayi | Fibulin-1 precursor | 0.0214 | 0.0972 | 0.2965 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0495 | 0.6603 | 0.6238 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 7.6 % | Antiallergic activity determined by passive cutaneous anaphylaxis assay upon peroral administration of 20 mg/kg in rat | ChEMBL. | 2465410 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.