Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0143 | 0.1018 | 0.1018 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0379 | 0.3807 | 0.1373 |
Loa Loa (eye worm) | ryanodine receptor | 0.0175 | 0.1393 | 0.4938 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0169 | 0.1321 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.2821 | 1 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0169 | 0.1321 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0116 | 0.0691 | 0.0691 |
Loa Loa (eye worm) | ryanodine receptor | 0.0111 | 0.0632 | 0.224 |
Schistosoma mansoni | ryanodine receptor related | 0.0468 | 0.486 | 0.486 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.0468 | 0.486 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0379 | 0.3807 | 0.1373 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0379 | 0.1344 |
Schistosoma mansoni | tyrosine kinase | 0.0883 | 0.9755 | 0.9755 |
Schistosoma mansoni | tyrosine kinase | 0.0904 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0115 | 0.0682 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0904 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0335 | 0.1189 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0 | Anticonvulsant activity was evaluated by subcutaneous pentylenetetrazole (Metrazol) (sc Met) seizure test at dose 600 mg/kg; No activity | ChEMBL. | 3989820 |
Activity (functional) | = 0 | Anticonvulsant activity was evaluated by Neurologic toxicity (the rotorod test) at dose 600 mg/kg; No activity | ChEMBL. | 3989820 |
Activity (functional) | = 0 | Anticonvulsant activity was evaluated by maximal electroshock seizure (MES) test at dose 600 mg/kg; No activity | ChEMBL. | 3989820 |
Activity (functional) | = 0 | Anticonvulsant activity was evaluated by maximal electroshock seizure (MES) test at dose 600 mg/kg; No activity | ChEMBL. | 3989820 |
Activity (functional) | = 0 | Anticonvulsant activity was evaluated by subcutaneous pentylenetetrazole (Metrazol) (sc Met) seizure test at dose 600 mg/kg; No activity | ChEMBL. | 3989820 |
Activity (functional) | = 0 | Anticonvulsant activity was evaluated by Neurologic toxicity (the rotorod test) at dose 600 mg/kg; No activity | ChEMBL. | 3989820 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.