Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase eta, putative | 0.004 | 0.0081 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.2653 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.0673 | 0.0597 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.0673 | 0.0597 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.004 | 0.1053 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0141 | 0.0462 | 0.0384 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.029 | 0.1027 | 0.0954 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.029 | 0.1027 | 0.0954 |
Echinococcus multilocularis | GPCR, family 2 | 0.0141 | 0.0462 | 0.0384 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.029 | 0.1027 | 0.0954 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.004 | 0.5 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.1076 | 0.4012 | 0.3963 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.004 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.029 | 0.1027 | 0.0954 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0141 | 0.0462 | 0.0462 |
Echinococcus granulosus | GPCR family 2 | 0.0141 | 0.0462 | 0.0384 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.029 | 0.1027 | 0.0954 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0445 | 0.1617 | 0.1617 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.004 | 0.1053 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.004 | 0.1053 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0081 | 0.0041 |
Brugia malayi | MH2 domain containing protein | 0.0138 | 0.0453 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0462 | 0.0424 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.2653 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0445 | 0.1617 | 0.1617 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.004 | 0.0081 | 0.0081 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0196 | 0.0673 | 0.0673 |
Brugia malayi | hypothetical protein | 0.003 | 0.004 | 0.004 |
Echinococcus granulosus | tar DNA binding protein | 0.0196 | 0.0673 | 0.0597 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.1617 | 0.1584 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.029 | 0.1027 | 0.1027 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0141 | 0.0462 | 0.0424 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 0.0453 | 0.0414 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.0673 | 0.0597 |
Leishmania major | DNA polymerase eta, putative | 0.004 | 0.0081 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.004 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0196 | 0.0673 | 0.0635 |
Loa Loa (eye worm) | hypothetical protein | 0.2653 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.029 | 0.1027 | 0.0954 |
Brugia malayi | TAR-binding protein | 0.0196 | 0.0673 | 0.0673 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0141 | 0.0462 | 0.0384 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.0673 | 0.0597 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.2653 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0141 | 0.0462 | 0.0384 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.004 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0196 | 0.0673 | 0.0635 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.0462 | 0.0384 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.2653 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0445 | 0.1617 | 0.1584 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.1083 | 0.1047 |
Loa Loa (eye worm) | RNA binding protein | 0.0196 | 0.0673 | 0.0635 |
Onchocerca volvulus | 0.2653 | 1 | 0.5 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 0.0453 | 0.0414 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.2653 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.004 | 0.0081 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.2653 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0196 | 0.0673 | 0.0597 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0141 | 0.0462 | 0.0384 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.0462 | 0.0384 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.0462 | 0.0384 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0304 | 0.1083 | 0.1083 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.029 | 0.1027 | 0.0991 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.2653 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0141 | 0.0462 | 0.0462 |
Brugia malayi | RNA binding protein | 0.0196 | 0.0673 | 0.0673 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.1577 | 0.5916 | 0.5882 |
Schistosoma mansoni | hypothetical protein | 0.0304 | 0.1083 | 0.101 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.029 | 0.1027 | 0.0954 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.0673 | 0.0597 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.0462 | 0.0384 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Antifertility potency (functional) | = 150 | Antifertility activity measured as minimum protective dose for prevention of pregnancy in rats | ChEMBL. | 3560158 |
Estrogenic potency (functional) | = 17 | Evaluation of oral estrogenic activity by using immature female rats ovariectomized at 21 days of age. | ChEMBL. | 3560158 |
Separation (functional) | = 9 | Separation of antifertility from estrogenic activity in rats was measured | ChEMBL. | 3560158 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.