Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.123 | 0.123 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0339 | 0.2679 | 0.2679 |
Loa Loa (eye worm) | hypothetical protein | 0.0799 | 0.9498 | 0.9498 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0473 | 0.467 | 0.3631 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0269 | 0.1631 | 0.5 |
Brugia malayi | Fibulin-1 precursor | 0.0269 | 0.1631 | 0.7039 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0159 | 0 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0315 | 0.2318 | 0.2318 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0269 | 0.1631 | 0.7039 |
Brugia malayi | Matrixin family protein | 0.0315 | 0.2318 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0289 | 0.1931 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0159 | 0 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0185 | 0.0386 | 0.1666 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.1631 | 0.1631 |
Onchocerca volvulus | Arrow homolog | 0.0242 | 0.123 | 0.546 |
Loa Loa (eye worm) | matrixin family protein | 0.0289 | 0.1931 | 0.1931 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0269 | 0.1631 | 0.1631 |
Loa Loa (eye worm) | AStacin protease | 0.0521 | 0.537 | 0.537 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0269 | 0.1631 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0473 | 0.467 | 0.3631 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0242 | 0.123 | 0.5307 |
Schistosoma mansoni | egf-like domain protein | 0.0242 | 0.123 | 0.0878 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0242 | 0.123 | 0.123 |
Mycobacterium ulcerans | hydrolase | 0.0159 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.123 | 0.123 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0833 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0289 | 0.1931 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | NSE 0 % | Compound was tested for antiinflammatory activity in rats by carrageenam edema test after peroral administration of 200 mg/kg dose; no significant effect | ChEMBL. | 7241523 |
Inhibition (functional) | = 29 % | Compound was tested for antiinflammatory activity in rats by adjuvant arthritis test after peroral administration of 50 mg/kg dose | ChEMBL. | 7241523 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.