Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.1882 | 0.1882 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0441 | 0.1882 | 0.8351 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0491 | 0.2253 | 0.2253 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0491 | 0.2253 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0491 | 0.2253 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.1882 | 0.1882 |
Loa Loa (eye worm) | hypothetical protein | 0.1459 | 0.9535 | 0.9535 |
Loa Loa (eye worm) | hypothetical protein | 0.0619 | 0.3223 | 0.3223 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0512 | 0.2415 | 0.0209 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.1521 | 1 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0441 | 0.1882 | 0.1827 |
Loa Loa (eye worm) | matrixin family protein | 0.034 | 0.1125 | 0.1125 |
Brugia malayi | Matrixin family protein | 0.034 | 0.1125 | 0.4994 |
Brugia malayi | Hemopexin family protein | 0.02 | 0.0067 | 0.0295 |
Echinococcus multilocularis | Tolloid protein 1 | 0.1521 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0312 | 0.0914 | 0.4855 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.1521 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0491 | 0.2253 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0441 | 0.1882 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0312 | 0.0914 | 0.0914 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.2253 | 0.2253 |
Brugia malayi | Fibulin-1 precursor | 0.0491 | 0.2253 | 1 |
Onchocerca volvulus | 0.02 | 0.0067 | 0.0354 | |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0312 | 0.0914 | 0.4855 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0512 | 0.2415 | 0.0209 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0441 | 0.1882 | 0.1882 |
Loa Loa (eye worm) | AStacin protease | 0.0951 | 0.5714 | 0.5714 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Acute toxicity (ADMET) | Toxicity of the compound tested in mouse and expressed as number of dead mouse / number of mouse used after a dose of 1.0 g/kg perorally; + slight toxicity | ChEMBL. | 1995885 | |
Acute toxicity (ADMET) | 0 | Toxicity of the compound tested in mouse and expressed as number of dead mouse / number of mouse used after a dose of 1.0 g/kg perorally; + slight toxicity | ChEMBL. | 1995885 |
GE (functional) | = 43 % | Gastric emptying of phenol red semisolid meal in rats at dose of 2.0 mg/kg ,administered perorally. | ChEMBL. | 1995885 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.