Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.4609 | 0.4609 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0093 | 0.9469 | 0.9469 |
Loa Loa (eye worm) | POT family protein | 0.0043 | 0.1165 | 0.1165 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0093 | 0.9469 | 0.9469 |
Schistosoma mansoni | transient receptor potential channel | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.4079 | 0.4079 |
Brugia malayi | POT family protein | 0.0043 | 0.1165 | 1 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0096 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 1 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.4609 | 0.4609 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.4609 | 0.4609 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.4609 | 0.4609 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 15.3 nM | Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]-Rauwolscine as radioligand | ChEMBL. | 10762040 |
Ki (binding) | = 188.6 nM | Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]-Rauwolscine as radioligand | ChEMBL. | 10762040 |
Selectivity (binding) | = 12.3 | Selectivity for alpha2a to that of alpha2b determined by their binding affinity ratios | ChEMBL. | 10762040 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.