Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor NMDA | 0.1409 | 0.7705 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0534 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0534 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0534 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1669 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0927 | 0.3462 | 0.1992 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0534 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1034 | 0.4402 | 0.3145 |
Chlamydia trachomatis | glutamine binding protein | 0.0534 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.1034 | 0.4402 | 0.1439 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0534 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (functional) | = 14 ng ml-1 | Compound was measured for the 50% growth inhibition of S. faecium ATCC8043 microorganism. | ChEMBL. | 6767031 |
I50 (functional) | = 240 ng ml-1 | Compound was measured for the 50% growth inhibition of L. casei ATCC7469 microorganism. | ChEMBL. | 6767031 |
I50 (functional) | = 520 ng ml-1 | Compound was measured for the 50% growth inhibition of S. faecium MTX resistant microorganism. | ChEMBL. | 6767031 |
I50 (functional) | = 700 ng ml-1 | Compound was measured for the 50% growth inhibition of L. casei MTX resistant microorganism. | ChEMBL. | 6767031 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.