Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | DNA gyrase (type II topoisomerase), subunit A | Starlite/ChEMBL | References |
Escherichia coli | DNA gyrase, subunit B | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE HYDROLASE | 0.2044 | 0.3279 | 1 |
Brugia malayi | Hemopexin family protein | 0.238 | 0.3835 | 0.5793 |
Loa Loa (eye worm) | hypothetical protein | 0.1678 | 0.2674 | 0.4035 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.1678 | 0.2674 | 0.6965 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0121 | 0.0095 | 0.5 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0318 | 0.042 | 1 |
Schistosoma mansoni | hypothetical protein | 0.238 | 0.3835 | 1 |
Brugia malayi | Matrixin family protein | 0.4058 | 0.6615 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.3723 | 0.6059 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.3723 | 0.6059 | 0.9159 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0318 | 0.042 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.6103 | 1 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0121 | 0.0095 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.4058 | 0.6615 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.0095 | 0.5 |
Onchocerca volvulus | 0.1678 | 0.2674 | 0.4405 | |
Plasmodium falciparum | DNA gyrase subunit B | 0.0153 | 0.0147 | 0.3378 |
Brugia malayi | Matrixin family protein | 0.1678 | 0.2674 | 0.4035 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0088 | 0.004 | 0.0788 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0069 | 0.0008 | 0.5 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0318 | 0.042 | 0.0872 |
Brugia malayi | Matrixin family protein | 0.1678 | 0.2674 | 0.4035 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.3723 | 0.6059 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0064 | 0 | 0.5 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0153 | 0.0147 | 0.3378 |
Loa Loa (eye worm) | hypothetical protein | 0.2044 | 0.3279 | 0.4952 |
Loa Loa (eye worm) | hypothetical protein | 0.1678 | 0.2674 | 0.4035 |
Loa Loa (eye worm) | hypothetical protein | 0.1678 | 0.2674 | 0.4035 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0153 | 0.0147 | 0.2419 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0318 | 0.042 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.2044 | 0.3279 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0069 | 0.0008 | 0.5 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.1678 | 0.2674 | 0.4035 |
Brugia malayi | Matrixin family protein | 0.1678 | 0.2674 | 0.4035 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.0095 | 0.5 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0318 | 0.042 | 0.0872 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0318 | 0.042 | 1 |
Mycobacterium ulcerans | hydrolase | 0.2044 | 0.3279 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0318 | 0.042 | 1 |
Brugia malayi | Matrixin family protein | 0.1678 | 0.2674 | 0.4035 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0318 | 0.042 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.1678 | 0.2674 | 0.4405 |
Onchocerca volvulus | 0.238 | 0.3835 | 0.6325 | |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.2044 | 0.3279 | 0.4952 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0865 | 0.1326 | 0.3443 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 6.3 ug ml-1 | Compound evaluated in vitro for the ability to inhibit gyrase. | ChEMBL. | 1995890 |
IC50 (binding) | = 6.3 ug ml-1 | Compound evaluated in vitro for the ability to inhibit gyrase. | ChEMBL. | 1995890 |
MIC (functional) | = 0.26 | Compound evaluated in vitro against five gram-positive bacterial strains and geometric means of the minimum inhibitory concentrations (MIC) reported. | ChEMBL. | 1995890 |
MIC (functional) | = 0.46 | Compound evaluated in vitro against five gram-negative bacterial strains and geometric means of the minimum inhibitory concentrations (MIC) reported. | ChEMBL. | 1995890 |
PD50 (functional) | = 2.8 mg kg-1 | In vivo protection against gram-positive E. coli vogel in mouse after oral administration. | ChEMBL. | 1995890 |
PD50 (functional) | = 2.8 mg kg-1 | In vivo protection against gram-positive E. coli vogel in mouse after subcutaneous administration | ChEMBL. | 1995890 |
PD50 (functional) | = 2.8 mg kg-1 | In vivo protection against gram-positive E. coli vogel in mouse after oral administration. | ChEMBL. | 1995890 |
PD50 (functional) | = 2.8 mg kg-1 | In vivo protection against gram-positive E. coli vogel in mouse after subcutaneous administration | ChEMBL. | 1995890 |
PD50 (functional) | = 16 mg kg-1 | In vivo protection against gram-positive Streptococcus pneumonia (SV-1) in mouse after subcutaneous administration | ChEMBL. | 1995890 |
PD50 (functional) | = 23 mg kg-1 | In vivo protection against gram-positive Streptococcus pneumonia (SV-1) in mouse after oral administration. | ChEMBL. | 1995890 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.