Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0771 | 0.3081 | 0.2358 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0982 | 0.5047 | 1 |
Schistosoma mansoni | integrin alpha | 0.0982 | 0.5047 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0743 | 0.2818 | 0.2068 |
Echinococcus multilocularis | integrin alpha 3 | 0.0753 | 0.2911 | 1 |
Echinococcus granulosus | integrin alpha 3 | 0.0753 | 0.2911 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
BK (functional) | = 25 % | Blockade of peak steady-state K+ currents of neuroblastoma cells N1E-115 at 25 uM | ChEMBL. | 11312924 |
BK (functional) | = 25 % | Blockade of peak steady-state K+ currents of neuroblastoma cells N1E-115 at 25 uM | ChEMBL. | 11312924 |
BK (functional) | = 42 % | Blockade of peak steady-state K+ currents of neuroblastoma cells N1E-115 at 50 microM concentration | ChEMBL. | 11312924 |
BK (functional) | = 42 % | Blockade of peak steady-state K+ currents of neuroblastoma cells N1E-115 at 50 microM concentration | ChEMBL. | 11312924 |
BK (functional) | = 44 % | Blockade of peak steady-state K+ currents of Kv1.3 channels in mouse fibroblasts L929 at 25 uM | ChEMBL. | 11312924 |
BK (functional) | = 44 % | Blockade of peak steady-state K+ currents of Kv1.3 channels in mouse fibroblasts L929 at 25 uM | ChEMBL. | 11312924 |
BK (functional) | = 70 % | Blockade of peak steady-state K+ currents of Kv1.3 channels in mice fibroblasts L929 at 50 microM concentration | ChEMBL. | 11312924 |
BK (functional) | = 70 % | Blockade of peak steady-state K+ currents of Kv1.3 channels in mice fibroblasts L929 at 50 microM concentration | ChEMBL. | 11312924 |
BNa (functional) | = 0 % | Blockade of peak steady-state Na+ currents of neuroblastoma cells N1E-115 at 25 uM | ChEMBL. | 11312924 |
BNa (functional) | = 0 % | Blockade of peak steady-state Na+ currents of neuroblastoma cells N1E-115 at 25 uM | ChEMBL. | 11312924 |
BNa (functional) | = 11 % | Blockade of peak steady-state Na+ currents of neuroblastoma cells N1E-115 at 50 microM concentration | ChEMBL. | 11312924 |
BNa (functional) | = 11 % | Blockade of peak steady-state Na+ currents of neuroblastoma cells N1E-115 at 50 microM concentration | ChEMBL. | 11312924 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.