Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | growth factor receptor-bound protein 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | growth factor receptor-bound protein 2 | 217 aa | 200 aa | 23.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protection of telomeres protein 1 | 0.0603 | 0.0397 | 1 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0152 | 0.0094 | 1 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0152 | 0.0094 | 0.0129 |
Brugia malayi | hypothetical protein | 0.0119 | 0.0072 | 0.0099 |
Schistosoma mansoni | hypothetical protein | 0.0119 | 0.0072 | 0.7648 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0152 | 0.0094 | 0.2368 |
Brugia malayi | Telomerase reverse transcriptase | 1.0841 | 0.7266 | 1 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0152 | 0.0094 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0072 | 0.7648 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0072 | 0.7648 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.4074 | 0.2726 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.4074 | 0.2726 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.4074 | 0.2726 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.4074 | 0.2726 | 0.5 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0152 | 0.0094 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.4074 | 0.2726 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.4074 | 0.2726 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.4074 | 0.2726 | 0.5 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0152 | 0.0094 | 0.2368 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.4074 | 0.2726 | 0.5 |
Echinococcus multilocularis | protection of telomeres protein 1 | 0.0603 | 0.0397 | 1 |
Brugia malayi | hypothetical protein | 0.0119 | 0.0072 | 0.0099 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 18 nM | Dissociation constant of compound was determined from affinity of compound towards Growth factor receptor bound protein 2 measured by fluorescence | ChEMBL. | 10762050 |
Kd (binding) | = 18 nM | Dissociation constant of compound was determined from affinity of compound towards Growth factor receptor bound protein 2 measured by fluorescence | ChEMBL. | 10762050 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.