Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Analgesia (functional) | = 14 % | Percentage analgesia determined by mouse hot plate assay (1 mg/kg) | ChEMBL. | 2563773 |
Analgesia (functional) | = 14 % | Percentage analgesia determined by mouse hot plate assay (1 mg/kg) | ChEMBL. | 2563773 |
Analgesia (functional) | = 100 % | Percentage analgesia of determined by mouse hot plate assay (5 mg/kg) | ChEMBL. | 2563773 |
Analgesia (functional) | = 100 % | Percentage analgesia of determined by mouse hot plate assay (5 mg/kg) | ChEMBL. | 2563773 |
Ki (binding) | nM | The ability of the compound to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane; ND is not determined. | ChEMBL. | 2563773 |
Ki (binding) | 0 nM | The ability of the compound to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane; ND is not determined. | ChEMBL. | 2563773 |
Reversal (functional) | 0 % | Percentage analgesia after treatment with compound or morphine in rabbit | ChEMBL. | 2563773 |
Reversal (functional) | = 31 % | Percentage of respirations per minute after treatment with morphine when compared to control in rabbit | ChEMBL. | 2563773 |
Reversal (functional) | = 43 % | Percentage of respirations per minute after treatment in rabbit | ChEMBL. | 2563773 |
Reversal type (functional) | = 0 | Ability of compound for reversal of morphine and analgesia was determined; 0= reversal not observed. | ChEMBL. | 2563773 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.