Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | DNA gyrase, subunit B | References | |
Escherichia coli | DNA gyrase (type II topoisomerase), subunit A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | telomerase reverse transcriptase | 0.269 | 0.2688 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.269 | 0.2688 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.0066 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0153 | 0.0097 | 0.0321 |
Brugia malayi | Telomerase reverse transcriptase | 0.7158 | 0.7252 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0318 | 0.0266 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.0065 | 0.0241 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0153 | 0.0097 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0066 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0069 | 0.0011 | 0.5 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0318 | 0.0266 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0121 | 0.0065 | 0.0241 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0153 | 0.0097 | 0.0321 |
Echinococcus multilocularis | protection of telomeres protein 1 | 0.0622 | 0.0576 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0318 | 0.0266 | 0.095 |
Brugia malayi | hypothetical protein | 0.0123 | 0.0066 | 0.0076 |
Giardia lamblia | Telomerase catalytic subunit | 0.269 | 0.2688 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.269 | 0.2688 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.269 | 0.2688 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.269 | 0.2688 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0318 | 0.0266 | 0.095 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0152 | 0.0096 | 0.5 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0318 | 0.0266 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0318 | 0.0266 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0318 | 0.0266 | 1 |
Brugia malayi | hypothetical protein | 0.0123 | 0.0066 | 0.0076 |
Echinococcus granulosus | protection of telomeres protein 1 | 0.0622 | 0.0576 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.269 | 0.2688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0066 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.0065 | 0.0241 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.269 | 0.2688 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0088 | 0.0031 | 0.0075 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0318 | 0.0266 | 0.095 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0121 | 0.0065 | 0.0241 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0069 | 0.0011 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 1.8 ug ml-1 | Compound evaluated in vitro for the ability to inhibit gyrase. | ChEMBL. | 1995890 |
IC50 (binding) | = 1.8 ug ml-1 | Compound evaluated in vitro for the ability to inhibit gyrase. | ChEMBL. | 1995890 |
MIC (functional) | = 0.06 | Compound evaluated in vitro against five gram-positive bacterial strains and geometric means of the minimum inhibitory concentrations (MIC) reported. | ChEMBL. | 1995890 |
MIC (functional) | = 0.08 | Compound evaluated in vitro against five gram-negative bacterial strains and geometric means of the minimum inhibitory concentrations (MIC) reported. | ChEMBL. | 1995890 |
PD50 (functional) | = 1.6 mg kg-1 | In vivo protection against gram-positive E. coli vogel in mouse after subcutaneous administration | ChEMBL. | 1995890 |
PD50 (functional) | = 1.6 mg kg-1 | In vivo protection against gram-positive E. coli vogel in mouse after subcutaneous administration | ChEMBL. | 1995890 |
PD50 (functional) | = 5.7 mg kg-1 | In vivo protection against gram-positive E. coli vogel in mouse after oral administration. | ChEMBL. | 1995890 |
PD50 (functional) | = 5.7 mg kg-1 | In vivo protection against gram-positive E. coli vogel in mouse after oral administration. | ChEMBL. | 1995890 |
PD50 (functional) | = 6.6 mg kg-1 | In vivo protection against gram-positive Streptococcus pneumonia (SV-1) in mouse after subcutaneous administration | ChEMBL. | 1995890 |
PD50 (functional) | > 100 mg kg-1 | In vivo protection against gram-positive Streptococcus pneumonia (SV-1) in mouse after oral administration. | ChEMBL. | 1995890 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.