Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1346 | 0.5859 | 0.5859 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.1698 | 1 | 0.5 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.1698 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.1698 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1346 | 0.5859 | 0.5859 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.1698 | 1 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1346 | 0.5859 | 0.5 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.1698 | 1 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.1698 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1698 | 1 | 1 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.1346 | 0.5859 | 0.5859 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 17 % | Inhibition of Phosphodiesterase 4 (PDE4) from guinea pig ventricle at 200 uM | ChEMBL. | 10691694 |
Inhibition (binding) | = 17 % | Inhibition of Phosphodiesterase 4 (PDE4) from guinea pig ventricle at 200 uM | ChEMBL. | 10691694 |
Inhibition (binding) | = 22 % | Inhibition of Phosphodiesterase 3 (PDE3) from guinea pig ventricle at 200 uM | ChEMBL. | 10691694 |
Inhibition (binding) | = 22 % | Inhibition of Phosphodiesterase 3 (PDE3) from guinea pig ventricle at 200 uM | ChEMBL. | 10691694 |
Inhibition (binding) | = 40 % | Inhibition of human Phosphodiesterase 7A expressed in S. cerevisiae at 200 uM | ChEMBL. | 10691694 |
Inhibition (binding) | = 40 % | Inhibition of human Phosphodiesterase 7A expressed in S. cerevisiae at 200 uM | ChEMBL. | 10691694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.