Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glutamate receptor 2 precursor | 0.1161 | 0.1073 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0957 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1183 | 0.1185 | 0.0125 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.2862 | 1 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0957 | 0 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0957 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.1414 | 0.2398 | 0.1484 |
Schistosoma mansoni | glutamate receptor NMDA | 0.2631 | 0.8787 | 0.5 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.1395 | 0.2303 | 0.1377 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.1161 | 0.1073 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.1161 | 0.1073 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0957 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0957 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1183 | 0.1185 | 0.0125 |
Echinococcus multilocularis | glutamate receptor 2 | 0.1395 | 0.2303 | 0.1377 |
Echinococcus granulosus | glutamate receptor NMDA | 0.1448 | 0.258 | 0.1583 |
Chlamydia trachomatis | glutamine binding protein | 0.0957 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.1683 | 0.381 | 0.2978 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1183 | 0.1185 | 0.0125 |
Echinococcus granulosus | glutamate receptor 2 | 0.1395 | 0.2303 | 0.1268 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1683 | 0.381 | 0.3066 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.1395 | 0.2303 | 0.1268 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.1448 | 0.258 | 0.1688 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity A (functional) | = 0.9 uM kg-1 | Reduction of the integrated electromyographic response by 50% in cat after intravenous administration | ChEMBL. | 7392031 |
Activity B (functional) | = 5.5 uM kg-1 | Dose of compound to reduce the integrated electromyographic response by 50% in cat after peroral administration; Range is 5.5-13.7 | ChEMBL. | 7392031 |
Locomotor activity (functional) | = 57 uM kg-1 | Reduction of locomotor activity count to 50% of the control in mouse after oral administration | ChEMBL. | 7392031 |
Locomotor activity (functional) | = 57 uM kg-1 | Reduction of locomotor activity count to 50% of the control in mouse after oral administration | ChEMBL. | 7392031 |
Ratio (functional) | = 63 | Ratio of motor activity and activity A | ChEMBL. | 7392031 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.