Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | glutamine binding protein | 0.0957 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.1448 | 0.258 | 0.1583 |
Echinococcus multilocularis | glutamate receptor 2 | 0.1395 | 0.2303 | 0.1377 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1183 | 0.1185 | 0.0125 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.1448 | 0.258 | 0.1688 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.1395 | 0.2303 | 0.1268 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1683 | 0.381 | 0.3066 |
Echinococcus granulosus | glutamate receptor 2 | 0.1395 | 0.2303 | 0.1268 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1183 | 0.1185 | 0.0125 |
Echinococcus granulosus | nmda type glutamate receptor | 0.1683 | 0.381 | 0.2978 |
Schistosoma mansoni | glutamate receptor NMDA | 0.2631 | 0.8787 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.1414 | 0.2398 | 0.1484 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0957 | 0 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0957 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.2862 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1183 | 0.1185 | 0.0125 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0957 | 0 | 0.5 |
Brugia malayi | Glutamate receptor 2 precursor | 0.1161 | 0.1073 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0957 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0957 | 0 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.1161 | 0.1073 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.1161 | 0.1073 | 0.5 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.1395 | 0.2303 | 0.1377 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity A (functional) | = 2.08 uM kg-1 | Reduction of the integrated electromyographic response by 50% in cat after intravenous administration | ChEMBL. | 7392031 |
Activity B (functional) | > 13 uM kg-1 | Reduction of the integrated electromyographic response by 50% in cat after peroral administration | ChEMBL. | 7392031 |
Locomotor activity (functional) | = 377 uM kg-1 | Reduction of locomotor activity count to 50% of the control in mouse after oral administration | ChEMBL. | 7392031 |
Locomotor activity (functional) | = 377 uM kg-1 | Reduction of locomotor activity count to 50% of the control in mouse after oral administration | ChEMBL. | 7392031 |
Ratio (functional) | = 181 | Ratio of motor activity and activity A | ChEMBL. | 7392031 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.