Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0878 | 0.1553 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0878 | 0.1553 | 0.1553 |
Mycobacterium ulcerans | hypothetical protein | 0.0878 | 0.1553 | 0.1553 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0221 | 0.0134 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0159 | 0 | 0.5 |
Treponema pallidum | licC protein (licC) | 0.0878 | 0.1553 | 1 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0159 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.479 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0878 | 0.1553 | 0.1553 |
Mycobacterium ulcerans | molybdopterin-guanine dinucleotide biosynthesis protein A | 0.0878 | 0.1553 | 0.1553 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0878 | 0.1553 | 0.1553 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.479 | 1 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.479 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0221 | 0.0134 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0221 | 0.0134 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Antagonist activity (functional) | 0 | Antagonist activity was evaluated by NMDA-induced excitations of feline spinal neuron; activity is seen | ChEMBL. | 2859375 |
IC50 (functional) | = 64 uM | Inhibition of [3H]-AMPA binding in rat brain membrane was evaluated | ChEMBL. | 2859375 |
Relative potency (functional) | 0 | GDEE-sensitive neuronal excitant (Relative potency) was evaluated; no activity | ChEMBL. | 2859375 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.