Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.0101 | 0.0101 |
Echinococcus multilocularis | integrin alpha ps | 0.0616 | 0.1273 | 0.1792 |
Loa Loa (eye worm) | hypothetical protein | 0.0758 | 0.1837 | 0.1837 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.1374 | 0.4282 | 0.3965 |
Schistosoma mansoni | integrin alpha-ps | 0.0321 | 0.0101 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 0.311 | 0.311 |
Echinococcus granulosus | integrin beta 2 | 0.2085 | 0.7104 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.0616 | 0.1273 | 0.1792 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.1039 | 0.2954 | 0.2563 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0428 | 0.0525 | 0.0525 |
Loa Loa (eye worm) | hypothetical protein | 0.1039 | 0.2954 | 0.2954 |
Schistosoma mansoni | integrin alpha | 0.1374 | 0.4282 | 0.7921 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.2118 | 0.7236 | 0.7236 |
Echinococcus multilocularis | integrin beta 2 | 0.2085 | 0.7104 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.2814 | 1 | 1 |
Schistosoma mansoni | integrin beta subunit | 0.1657 | 0.5407 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.0525 | 0.0525 |
Echinococcus multilocularis | integrin alpha 3 | 0.1053 | 0.3009 | 0.4236 |
Schistosoma mansoni | integrin alpha-ps | 0.0616 | 0.1273 | 0.2355 |
Echinococcus multilocularis | integrin alpha ps | 0.0616 | 0.1273 | 0.1792 |
Echinococcus granulosus | integrin alpha 3 | 0.1053 | 0.3009 | 0.4236 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Amnesia reversal (functional) | = 17 % | Ability to reverse electroconvulsive shock (ECS) induced amnesia in mice, after administering intraperitoneally, at a dose of 5 mg/kg | ChEMBL. | 6716406 |
Amnesia reversal (functional) | = 17 % | Ability to reverse electroconvulsive shock (ECS) induced amnesia in mice, after administering intraperitoneally, at a dose of 5 mg/kg | ChEMBL. | 6716406 |
Amnesia reversal (functional) | = 42 % | Ability to reverse electroconvulsive shock induced amnesia in mice, after administering intraperitoneally at a dose of 20 mg/kg | ChEMBL. | 6716406 |
Amnesia reversal (functional) | = 42 % | Ability to reverse electroconvulsive shock induced amnesia in mice, after administering intraperitoneally at a dose of 20 mg/kg | ChEMBL. | 6716406 |
Amnesia reversal (functional) | = 61 % | Ability to reverse electroconvulsive shock (ECS) induced amnesia in mice, after administering intraperitoneally, at a dose of 80 mg/kg | ChEMBL. | 6716406 |
Amnesia reversal (functional) | = 61 % | Ability to reverse electroconvulsive shock (ECS) induced amnesia in mice, after administering intraperitoneally, at a dose of 80 mg/kg | ChEMBL. | 6716406 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.