Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0121 | 0 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0121 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0168 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0121 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0168 | 1 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0121 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0121 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0121 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 78 % | Inhibition of Calcium Ionophore (A-23187)-stimulated LTB4 formation in Human Neutrophil assay at a concentration of of 780 microM | ChEMBL. | 10691695 |
Inhibition (functional) | = 78 % | Inhibition of Calcium Ionophore (A-23187)-stimulated LTB4 formation in Human Neutrophil assay at a concentration of of 780 microM | ChEMBL. | 10691695 |
NT (functional) | 0 | Effective dose for in vivo ionophore-induced rat pleurisy. | ChEMBL. | 10691695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.