Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Rattus norvegicus | Histamine H3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | biogenic amine 5HT receptor | Histamine H3 receptor | 445 aa | 405 aa | 25.2 % |
Loa Loa (eye worm) | hypothetical protein | Histamine H3 receptor | 445 aa | 384 aa | 22.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0057 | 0.1882 | 0.8351 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0064 | 0.2253 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0057 | 0.1882 | 0.1882 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1882 | 0.1882 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0064 | 0.2253 | 0.2253 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.9535 | 0.9535 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.3223 | 0.3223 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0064 | 0.2253 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0198 | 1 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0198 | 1 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0198 | 1 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.0064 | 0.2253 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0064 | 0.2253 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1882 | 0.1882 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2253 | 0.2253 |
Onchocerca volvulus | Arrow homolog | 0.0057 | 0.1882 | 1 |
Loa Loa (eye worm) | AStacin protease | 0.0124 | 0.5714 | 0.5714 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -8.23 | Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells | ChEMBL. | 14741270 |
Ki (binding) | = -7.35 | Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes | ChEMBL. | 14741270 |
Ki (binding) | = 5.8 nM | Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells | ChEMBL. | 14741270 |
Ki (binding) | = 5.8 nM | Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells | ChEMBL. | 14741270 |
Ki (binding) | = 45 nM | Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes | ChEMBL. | 14741270 |
Ki (binding) | = 45 nM | Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes | ChEMBL. | 14741270 |
Log Ki (binding) | = 7.35 | Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes | ChEMBL. | 14741270 |
Log Ki (binding) | = 8.23 | Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells | ChEMBL. | 14741270 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.