Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0109 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0027 | 0.049 | 0.049 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0109 | 1 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0052 | 0.3357 | 0.3357 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0052 | 0.3357 | 0.3357 |
Brugia malayi | nuclear receptor NHR-67 | 0.0052 | 0.3357 | 0.3357 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3357 | 0.3357 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3357 | 0.3357 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0052 | 0.3357 | 0.3357 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0052 | 0.3357 | 0.3357 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0109 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0109 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3357 | 0.3357 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0109 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0052 | 0.3357 | 0.3357 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0109 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0024 | 0.019 | 0.019 |
Brugia malayi | nuclear hormone receptor | 0.0052 | 0.3357 | 0.3357 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0052 | 0.3357 | 0.3357 |
Brugia malayi | nuclear receptor RXR | 0.0052 | 0.3357 | 0.3357 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0052 | 0.3357 | 0.3357 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0052 | 0.3357 | 0.3357 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0052 | 0.3357 | 0.3357 |
Brugia malayi | nuclear receptor NHR-88 | 0.0052 | 0.3357 | 0.3357 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0027 | 0.049 | 0.049 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0052 | 0.3357 | 0.3357 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0024 | 0.019 | 0.019 |
Brugia malayi | nuclear hormone receptor | 0.0109 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0052 | 0.3357 | 0.3357 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0024 | 0.019 | 0.019 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0109 | 1 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0052 | 0.3357 | 0.3357 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.4068 | 0.4068 |
Brugia malayi | nuclear receptor RXR | 0.0058 | 0.4068 | 0.4068 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0109 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0109 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0109 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0109 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0109 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0109 | 1 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0052 | 0.3357 | 0.3357 |
Onchocerca volvulus | 0.0052 | 0.3357 | 0.3357 | |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0058 | 0.4068 | 0.4068 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3357 | 0.3357 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0109 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0058 | 0.4068 | 0.4068 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0109 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0052 | 0.3357 | 0.3357 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0052 | 0.3357 | 0.3357 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0052 | 0.3357 | 0.3357 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0109 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0109 | 1 | 1 |
Onchocerca volvulus | 0.0052 | 0.3357 | 0.3357 | |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0058 | 0.4068 | 0.4068 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0109 | 1 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0024 | 0.019 | 0.019 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0109 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0052 | 0.3357 | 0.3357 |
Schistosoma mansoni | coup transcription factor | 0.0109 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0052 | 0.3357 | 0.3357 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0027 | 0.049 | 0.049 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0109 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0052 | 0.3357 | 0.3357 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3357 | 0.3357 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3357 | 0.3357 |
Schistosoma mansoni | nuclear receptor | 0.0052 | 0.3357 | 0.3357 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0052 | 0.3357 | 0.3357 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0109 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3357 | 0.3357 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0109 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0052 | 0.3357 | 0.3357 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0109 | 1 | 1 |
Onchocerca volvulus | 0.0109 | 1 | 1 | |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0109 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0109 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0024 | 0.019 | 0.019 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0052 | 0.3357 | 0.3357 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0058 | 0.4068 | 0.4068 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.4068 | 0.4068 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0058 | 0.4068 | 0.4068 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3357 | 0.3357 |
Schistosoma mansoni | thyroid hormone receptor | 0.0109 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0109 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0109 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0109 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0109 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0052 | 0.3357 | 0.3357 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0052 | 0.3357 | 0.3357 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0052 | 0.3357 | 0.3357 |
Brugia malayi | tailless protein | 0.0052 | 0.3357 | 0.3357 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.4068 | 0.4068 |
Brugia malayi | conserved hypotetical protein | 0.0052 | 0.3357 | 0.3357 |
Brugia malayi | ecdysone receptor | 0.0052 | 0.3357 | 0.3357 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0024 | 0.019 | 0.019 |
Brugia malayi | hypothetical protein | 0.0058 | 0.4068 | 0.4068 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0052 | 0.3357 | 0.3357 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0109 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0109 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0052 | 0.3357 | 0.3357 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0109 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0052 | 0.3357 | 0.3357 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0024 | 0.019 | 0.019 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3357 | 0.3357 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0052 | 0.3357 | 0.3357 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0109 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0058 | 0.4068 | 0.4068 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0109 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0109 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0109 | 1 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0052 | 0.3357 | 0.3357 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0109 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0109 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0024 | 0.019 | 0.019 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0109 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0052 | 0.3357 | 0.3357 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3357 | 0.3357 |
Schistosoma mansoni | nuclear hormone receptor | 0.0109 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3357 | 0.3357 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0109 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0109 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0024 | 0.019 | 0.019 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0109 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0109 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0109 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0109 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3357 | 0.3357 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0109 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0109 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0109 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0109 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0052 | 0.3357 | 0.3357 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.4068 | 0.4068 |
Brugia malayi | hypothetical protein | 0.0052 | 0.3357 | 0.3357 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0024 | 0.019 | 0.019 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0109 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0109 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0109 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0024 | 0.019 | 0.019 |
Brugia malayi | steroid hormone receptor | 0.0109 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0109 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.4068 | 0.4068 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0109 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0058 | 0.4068 | 0.4068 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0109 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0058 | 0.4068 | 0.4068 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3357 | 0.3357 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0109 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 26 mg kg-1 | Tested for anticonvulsion activity in the metrazole-induced convulsion assays in mice after 30 min of ip administration | ChEMBL. | 9871630 |
IC50 (binding) | = 0.28 uM | In vitro binding affinity to the AMPA receptor using [3H]-AMPA binding assay | ChEMBL. | 9871630 |
Inhibition (binding) | = 0 % | In vitro binding affinity against glycine-bining site of NMDA receptor at a concentration of 1 uM using [3H]-MDL-105,519 binding assay | ChEMBL. | 9871630 |
Protection (functional) | = 40 % | Tested for anticonvulsion activity in the electroshock-induced convulsion assays in mice at 50 mg/kg after 30 min (i.p. administration ) | ChEMBL. | 9871630 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.