Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0354 | 0 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0354 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0354 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1054 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0562 | 0.2981 | 0.1259 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0354 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0916 | 0.8027 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0633 | 0.399 | 0.2516 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0354 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0633 | 0.399 | 0.1439 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0354 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -37 % | Percent change in triglycerides in hypercholesterolemic rats at a dose of 100 mg/kg/day for 8 days | ChEMBL. | 14736248 |
Change (functional) | = -35.8 % | Percent change in triglycerides following oral administration of compound in normal chow-fed rats at 100 mg/kg/day for 4 days | ChEMBL. | 14736248 |
Change (functional) | = 0 % | Percent change in very low-density lipoprotein cholesterol following oral administration of compound in normal chow-fed rats at 100 mg/kg/day for 4 days | ChEMBL. | 14736248 |
Change (functional) | = 6.8 % | Percent change in low-density lipoprotein cholesterol following oral administration of compound in normal chow-fed rats at 100 mg/kg/day for 4 days | ChEMBL. | 14736248 |
Change (functional) | = 53.4 % | Percent change in total plasma cholesterol in hypercholesterolemic rats dosed at 100 mg/kg/day for 8 days | ChEMBL. | 14736248 |
Change (functional) | = 57 % | Percent change in total plasma cholesterol following oral administration of compound in normal chow-fed rats at 100 mg/kg/day for 4 days | ChEMBL. | 14736248 |
Change (functional) | = 60.2 % | Percent change in high-density lipoprotein cholesterol following oral administration of compound in normal chow-fed rats at 100 mg/kg/day for 4 days | ChEMBL. | 14736248 |
Change (functional) | = 142 % | Percent change in high-density lipoprotein cholesterol in hypercholesterolemic rats dosed at 100 mg/kg/day for 8 days | ChEMBL. | 14736248 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.