Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0799 | 0.2528 | 0.2465 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0799 | 0.2528 | 0.2465 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0628 | 0.175 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0818 | 0.2615 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.2441 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.1304 | 0.4825 | 0.4781 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0628 | 0.175 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.048 | 0.1076 | 0.1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0799 | 0.2528 | 0.2465 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0628 | 0.175 | 0.168 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0628 | 0.175 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0628 | 0.175 | 0.1731 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0818 | 0.2615 | 0.5 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.0319 | 0.0345 | 0.0263 |
Schistosoma mansoni | glutamate receptor kainate | 0.0628 | 0.175 | 0.1731 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.1137 | 0.4068 | 0.4017 |
Echinococcus multilocularis | NMDA receptor | 0.0319 | 0.0345 | 0.0263 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0319 | 0.0345 | 0.0263 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0799 | 0.2528 | 0.2465 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0818 | 0.2615 | 0.5 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0319 | 0.0345 | 0.0263 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0319 | 0.0345 | 0.0263 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.0319 | 0.0345 | 0.0263 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0628 | 0.175 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.1475 | 0.5603 | 0.5566 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0799 | 0.2528 | 0.2465 |
Schistosoma mansoni | glutamate receptor kainate | 0.0628 | 0.175 | 0.1731 |
Schistosoma mansoni | glutamate receptor kainate | 0.0628 | 0.175 | 0.1731 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0818 | 0.2615 | 0.5 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0799 | 0.2528 | 0.2465 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0818 | 0.2615 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.2103 | 0.8461 | 1 |
Echinococcus granulosus | glutamate receptor NMDA | 0.1304 | 0.4825 | 0.4781 |
Echinococcus granulosus | glutamate receptor 2 | 0.048 | 0.1076 | 0.1 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0628 | 0.175 | 0.1731 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0818 | 0.2615 | 0.5 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0319 | 0.0345 | 0.0263 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0628 | 0.175 | 0.1731 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1475 | 0.5603 | 0.5566 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0799 | 0.2528 | 0.2465 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0628 | 0.175 | 0.1731 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0799 | 0.2528 | 0.2465 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0628 | 0.175 | 0.168 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0319 | 0.0345 | 0.0263 |
Echinococcus granulosus | glutamate receptor 2 | 0.0799 | 0.2528 | 0.2465 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0084 | 0.048 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0799 | 0.2528 | 0.2465 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0628 | 0.175 | 0.168 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | In vitro binding affinity against Tachykinin receptor 1 in rat whole forebrain membranes using [3H]-[Sar9Met(O2)]-SP binding assay | ChEMBL. | 11266174 |
IC50 (binding) | > 100 uM | In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H]-[Sar9Met(O2)]-SP binding assay | ChEMBL. | 11266174 |
IC50 (binding) | > 100 uM | In vitro binding affinity against Bradykinin receptor B2 in rat NG 108-15 neuroblastoma-glioma hybrid cell membranes using [3H]-BK binding assay | ChEMBL. | 11266174 |
IC50 (binding) | > 100 uM | In vitro binding affinity against Tachykinin receptor 1 in rat whole forebrain membranes using [3H]-[Sar9Met(O2)]-SP binding assay | ChEMBL. | 11266174 |
IC50 (binding) | > 100 uM | In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H]-[Sar9Met(O2)]-SP binding assay | ChEMBL. | 11266174 |
IC50 (binding) | > 100 uM | In vitro binding affinity against Bradykinin receptor B2 in rat NG 108-15 neuroblastoma-glioma hybrid cell membranes using [3H]-BK binding assay | ChEMBL. | 11266174 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.