Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.2289 | 0.3539 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0226 | 0.0242 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0028 | 0.0117 | 0.0067 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0031 | 0.0154 | 0.0295 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0466 | 0.0894 |
Echinococcus granulosus | twitchin | 0.0031 | 0.0161 | 0.0309 |
Echinococcus granulosus | Immunoglobulin | 0.0031 | 0.0154 | 0.0295 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0466 | 0.0625 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0466 | 0.0894 |
Mycobacterium ulcerans | orotidine 5'-phosphate decarboxylase | 0.0064 | 0.0687 | 1 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0024 | 0.0054 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.2646 | 0.5009 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0031 | 0.0154 | 0.0295 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0345 | 0.5208 | 0.5697 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0154 | 0.0126 |
Brugia malayi | hypothetical protein | 0.0118 | 0.1553 | 0.2362 |
Echinococcus granulosus | neuroglian | 0.0031 | 0.0154 | 0.0295 |
Chlamydia trachomatis | glutamine binding protein | 0.0024 | 0.0054 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1291 | 0.2368 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0345 | 0.5208 | 0.8206 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0033 | 0.0198 | 0.0197 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0033 | 0.0198 | 0.0197 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0345 | 0.5208 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0163 | 0.2289 | 0.3539 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0466 | 0.0761 |
Schistosoma mansoni | orotidine 5'-phosphate decarboxylase | 0.0064 | 0.0687 | 0.1193 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0031 | 0.0154 | 0.0295 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0031 | 0.0154 | 0.0295 |
Brugia malayi | bHLH-PAS transcription factor | 0.0039 | 0.0294 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.2536 | 0.3935 |
Brugia malayi | Cytochrome P450 family protein | 0.0028 | 0.0117 | 0.0067 |
Onchocerca volvulus | Deterin homolog | 0.0163 | 0.2289 | 0.2359 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0466 | 0.0894 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0035 | 0.0226 | 0.0434 |
Echinococcus multilocularis | Immunoglobulin | 0.0031 | 0.0154 | 0.0295 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0294 | 0.0564 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0031 | 0.0154 | 0.0153 |
Echinococcus multilocularis | roundabout 2 | 0.0031 | 0.0154 | 0.0295 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0345 | 0.5208 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0154 | 0.0126 |
Echinococcus granulosus | roundabout 2 | 0.0031 | 0.0154 | 0.0295 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0466 | 0.0625 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0345 | 0.5208 | 1 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0039 | 0.0294 | 0.0564 |
Loa Loa (eye worm) | orotate phosphoribosyltransferase | 0.0064 | 0.0687 | 0.0979 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0026 | 0.0075 | 0.0144 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0163 | 0.2289 | 0.3539 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0031 | 0.0154 | 0.0295 |
Schistosoma mansoni | nephrin | 0.0031 | 0.0154 | 0.0153 |
Mycobacterium ulcerans | putative regulatory protein | 0.0039 | 0.0294 | 0.3795 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0154 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.2289 | 0.3539 |
Brugia malayi | Kringle domain containing protein | 0.0035 | 0.0226 | 0.0242 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0345 | 0.5208 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0154 | 0.0126 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0031 | 0.0154 | 0.0126 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0034 | 0.0207 | 0.0398 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0345 | 0.5208 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0345 | 0.5208 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0034 | 0.0207 | 0.0398 |
Echinococcus granulosus | geminin | 0.0186 | 0.2646 | 0.5081 |
Echinococcus multilocularis | neuroglian | 0.0031 | 0.0154 | 0.0295 |
Plasmodium falciparum | orotidine 5'-phosphate decarboxylase | 0.0064 | 0.0687 | 0.0925 |
Plasmodium vivax | RNA helicase-1, putative | 0.0345 | 0.5208 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0035 | 0.0226 | 0.0434 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0294 | 0.0564 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0294 | 0.0426 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0026 | 0.0075 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0154 | 0.0126 |
Echinococcus multilocularis | uridine 5' monophosphate synthase | 0.0064 | 0.0687 | 0.1319 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0466 | 0.0761 |
Plasmodium vivax | orotidine 5'-phosphate decarboxylase, putative | 0.0064 | 0.0687 | 0.0925 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0031 | 0.0154 | 0.0295 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0294 | 0.0426 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0163 | 0.2289 | 0.4395 |
Brugia malayi | hypoxia-induced factor 1 | 0.0165 | 0.2313 | 0.3579 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0345 | 0.5208 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0163 | 0.2289 | 0.4313 |
Brugia malayi | Protein kinase domain containing protein | 0.0038 | 0.0271 | 0.0313 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0345 | 0.5208 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0165 | 0.2313 | 0.3579 |
Brugia malayi | Protein kinase domain containing protein | 0.0414 | 0.633 | 1 |
Echinococcus granulosus | single minded 2 | 0.0039 | 0.0294 | 0.0564 |
Echinococcus multilocularis | geminin | 0.0186 | 0.2646 | 0.5081 |
Trypanosoma cruzi | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | 0.0064 | 0.0687 | 0.0925 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0031 | 0.0154 | 0.0295 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0345 | 0.5208 | 1 |
Toxoplasma gondii | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase | 0.0064 | 0.0687 | 0.0925 |
Loa Loa (eye worm) | camk/mapkapk/mnk protein kinase | 0.0414 | 0.633 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0345 | 0.5208 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0345 | 0.5208 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0031 | 0.0154 | 0.0295 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0345 | 0.5208 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0031 | 0.0154 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0154 | 0.0126 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0226 | 0.0295 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0345 | 0.5208 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0101 | 0.1291 | 0.1335 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0031 | 0.0154 | 0.0153 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0031 | 0.0154 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0154 | 0.0126 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0163 | 0.2289 | 0.4395 |
Onchocerca volvulus | 0.0039 | 0.0294 | 0.0078 | |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0345 | 0.5208 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0038 | 0.0271 | 0.0313 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0345 | 0.5208 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0345 | 0.5208 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 0.4594 | 0.7224 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0154 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.5208 | 0.8206 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.2289 | 0.4313 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0163 | 0.2289 | 0.4313 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0053 | 0.0517 | 0.0861 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0345 | 0.5208 | 1 |
Echinococcus granulosus | uridine 5' monophosphate synthase | 0.0064 | 0.0687 | 0.1319 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0163 | 0.2289 | 0.4395 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0345 | 0.5208 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0345 | 0.5208 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0026 | 0.0075 | 0.0144 |
Brugia malayi | PAS domain containing protein | 0.0053 | 0.0517 | 0.0706 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0163 | 0.2289 | 0.4395 |
Onchocerca volvulus | 0.0578 | 0.8972 | 1 | |
Trypanosoma cruzi | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | 0.0064 | 0.0687 | 0.0925 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0031 | 0.0154 | 0.0295 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0345 | 0.5208 | 0.5 |
Brugia malayi | hypothetical protein | 0.0031 | 0.0154 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0154 | 0.0126 |
Leishmania major | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative | 0.0064 | 0.0687 | 0.0925 |
Brugia malayi | orotate phosphoribosyltransferase family protein | 0.0064 | 0.0687 | 0.0979 |
Mycobacterium leprae | Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (OMPDCase) (OMPdecase) | 0.0064 | 0.0687 | 0.5 |
Trypanosoma cruzi | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | 0.0064 | 0.0687 | 0.0925 |
Schistosoma mansoni | vesicular amine transporter | 0.0031 | 0.0154 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0154 | 0.0126 |
Schistosoma mansoni | cell adhesion molecule | 0.0031 | 0.0154 | 0.0153 |
Schistosoma mansoni | single-minded | 0.0053 | 0.0517 | 0.0861 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0466 | 0.0894 |
Brugia malayi | hypothetical protein | 0.0179 | 0.2536 | 0.3935 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0031 | 0.0154 | 0.0154 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0031 | 0.0154 | 0.0295 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0294 | 0.0349 |
Echinococcus granulosus | defective proboscis extension response | 0.0031 | 0.0154 | 0.0295 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.2646 | 0.5009 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0031 | 0.0154 | 0.0295 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0466 | 0.0761 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0034 | 0.0207 | 0.0398 |
Onchocerca volvulus | 0.0163 | 0.2289 | 0.2359 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 100 nM | [S]GTP gamma-S binding against adenosine A1 receptor in rat brain | ChEMBL. | 9871584 |
EC50 (binding) | = 6437 nM | Binding against human adenosine A1 receptor | ChEMBL. | 9871584 |
Ki (binding) | = 50 nM | Inhibition of [3H]-ZM-241,385 binding to human adenosine A2A receptor expressed in HeLa cells | ChEMBL. | 15267242 |
Ki (binding) | = 68 nM | Inhibition of [3H]-NECA binding to human adenosine A3 receptor expressed in HeLa cells | ChEMBL. | 15267242 |
Ki (binding) | = 302 nM | Inhibition of [3H]-DPCPX binding to human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 15267242 |
Ki (binding) | > 10000 nM | Inhibition of [3H]-DPCPX binding to human adenosine A2B receptor expressed in HEK-293 cells | ChEMBL. | 15267242 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.