Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arginine vasopressin receptor 2 | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | integrin alpha 3 | 0.0886 | 0.2938 | 0.2977 |
Schistosoma mansoni | integrin alpha-ps | 0.0518 | 0.1184 | 0.2209 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.036 | 0.0429 | 0.0429 |
Echinococcus granulosus | integrin alpha 3 | 0.0886 | 0.2938 | 0.2977 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0874 | 0.2882 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.0874 | 0.2882 | 0.2882 |
Schistosoma mansoni | integrin alpha | 0.1156 | 0.4224 | 0.7881 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.1781 | 0.7208 | 0.7208 |
Echinococcus multilocularis | integrin beta 2 | 0.1753 | 0.7075 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.2367 | 1 | 1 |
Schistosoma mansoni | integrin beta subunit | 0.1394 | 0.536 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0907 | 0.304 | 0.304 |
Echinococcus granulosus | integrin beta 2 | 0.1753 | 0.7075 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 0.0429 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0638 | 0.1754 | 0.1754 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.1156 | 0.4224 | 0.3965 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | nM | In vitro binding affinity to human V1a receptor; not tested | ChEMBL. | 10782666 |
IC50 (binding) | nM | In vitro binding affinity to rat V2 receptor; not tested | ChEMBL. | 10782666 |
IC50 (binding) | 0 nM | In vitro binding affinity to human V1a receptor; not tested | ChEMBL. | 10782666 |
IC50 (binding) | 0 nM | In vitro binding affinity to rat V2 receptor; not tested | ChEMBL. | 10782666 |
IC50 (binding) | = 1.7 nM | In vitro binding affinity to human V2 receptor | ChEMBL. | 10782666 |
IC50 (binding) | = 1.7 nM | In vitro binding affinity to human V2 receptor | ChEMBL. | 10782666 |
Urine volume (functional) | = 22 ml 4hr-1 | Urine volume was measured after 4 hours following oral compound dose of 3 mg/kg in rats deprived with food or water | ChEMBL. | 10782666 |
Urine volume (functional) | = 27 ml 4hr-1 | Urine volume was measured after 4 hours following oral compound dose of 10 mg/kg in a volume of 10 mL/kg (20% dimethylsulfoxide in 2.5% preboiled starch) in rats deprived with food or water | ChEMBL. | 10782666 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.