Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | integrin alpha | 0.0304 | 0.5047 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.2818 | 0.2068 |
Echinococcus multilocularis | integrin beta 2 | 0.0231 | 0.2839 | 0.9751 |
Echinococcus granulosus | integrin beta 2 | 0.0231 | 0.2839 | 0.9751 |
Echinococcus granulosus | integrin alpha 3 | 0.0233 | 0.2911 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.3081 | 0.2358 |
Loa Loa (eye worm) | integrin beta-2 | 0.0311 | 0.5267 | 0.4773 |
Echinococcus multilocularis | integrin alpha 3 | 0.0233 | 0.2911 | 1 |
Schistosoma mansoni | integrin beta subunit | 0.0183 | 0.1416 | 0.2805 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0311 | 0.5267 | 1 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0304 | 0.5047 | 0.9099 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Increase (functional) | = -2 % | Compound was tested in the rat after peroral administration for its ability to inhibit the in vivo blood platelet aggregation induced by collagen | ChEMBL. | 7097724 |
Increase (functional) | 0 % | Compound was tested in the rat after peroral administration for its ability to inhibit the in vivo blood platelet aggregation induced by collagen; Not determined | ChEMBL. | 7097724 |
S | = 25 mg ml-1 | Aqueous solubility at room temperature | ChEMBL. | 7097724 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.