Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0129 | 0.6756 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.6756 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Onchocerca volvulus | 0.0129 | 0.6756 | 0.5 | |
Onchocerca volvulus | 0.0129 | 0.6756 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Brugia malayi | Trypsin family protein | 0.0129 | 0.6756 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.0129 | 0.6756 | 0.5 |
Onchocerca volvulus | 0.0129 | 0.6756 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.6756 | 0.6756 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.6756 | 0.6756 |
Mycobacterium ulcerans | hypothetical protein | 0.0129 | 0.6756 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Onchocerca volvulus | 0.0129 | 0.6756 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Onchocerca volvulus | 0.0129 | 0.6756 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.6756 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0129 | 0.6756 | 0.5 |
Onchocerca volvulus | 0.0129 | 0.6756 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0129 | 0.6756 | 0.6756 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0129 | 0.6756 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Brugia malayi | Trypsin family protein | 0.0129 | 0.6756 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Brugia malayi | hypothetical protein | 0.0129 | 0.6756 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.6756 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.6756 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0129 | 0.6756 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.6756 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6756 | 0.6756 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.6756 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.6756 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 2 mg kg-1 | In vivo inhibition of ionophore induced rat pleurisy. | ChEMBL. | 10691695 |
IC50 (functional) | = 22 nM | Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay | ChEMBL. | 10691695 |
IC50 (functional) | = 22 nM | Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay | ChEMBL. | 10691695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.