Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Brugia malayi | nuclear hormone receptor | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0037 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0787 | 0.9749 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 0.9524 | 0.977 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0787 | 0.9749 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0037 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4 nM | Antagonistic activity against RAR gamma in transcriptional activation assay with 3.2 nM TTNPB | ChEMBL. | 10201840 |
IC50 (functional) | = 4 nM | Antagonistic activity against RAR gamma in transcriptional activation assay with 3.2 nM TTNPB | ChEMBL. | 10201840 |
IC50 (functional) | = 6.5 nM | Antagonistic activity against RAR alpha in transcriptional activation assay with 32 nM TTNPB | ChEMBL. | 10201840 |
IC50 (functional) | = 6.5 nM | Antagonistic activity against RAR beta in transcriptional activation assay with 10 nM TTNPB | ChEMBL. | 10201840 |
IC50 (functional) | = 6.5 nM | Antagonistic activity against RAR alpha in transcriptional activation assay with 32 nM TTNPB | ChEMBL. | 10201840 |
IC50 (functional) | = 6.5 nM | Antagonistic activity against RAR beta in transcriptional activation assay with 10 nM TTNPB | ChEMBL. | 10201840 |
Inhibition (functional) | = 97 % | Relative inhibition of TTNPB activity vs background activity (100% inhibition) against RAR alpha | ChEMBL. | 10201840 |
Inhibition (functional) | = 97 % | Relative inhibition of TTNPB activity vs background activity(100% inhibition) against RAR gamma | ChEMBL. | 10201840 |
Inhibition (functional) | = 97 % | Relative inhibition of TTNPB activity vs background activity (100% inhibition) against RAR alpha | ChEMBL. | 10201840 |
Inhibition (functional) | = 97 % | Relative inhibition of TTNPB activity vs background activity(100% inhibition) against RAR gamma | ChEMBL. | 10201840 |
Inhibition (functional) | = 98 % | Relative inhibition of TTNPB activity vs background activity (100% inhibition) against RAR beta | ChEMBL. | 10201840 |
Inhibition (functional) | = 98 % | Relative inhibition of TTNPB activity vs background activity (100% inhibition) against RAR beta | ChEMBL. | 10201840 |
Kd (binding) | = 12 nM | Binding affinity of [3H]- RA to baculovirus expressed human Retinoic acid receptor beta | ChEMBL. | 10201840 |
Kd (binding) | = 12 nM | Binding affinity of [3H]- RA to baculovirus expressed human Retinoic acid receptor beta | ChEMBL. | 10201840 |
Kd (binding) | = 17 nM | Binding affinity of [3H]- RA to baculovirus expressed human RAR alpha | ChEMBL. | 10201840 |
Kd (binding) | = 17 nM | Binding affinity of [3H]- RA to baculovirus expressed human RAR alpha | ChEMBL. | 10201840 |
Kd (binding) | = 33 nM | Binding affinity of [3H]- RA to baculovirus expressed human Retinoic acid receptor gamma | ChEMBL. | 10201840 |
Kd (binding) | = 33 nM | Binding affinity of [3H]- RA to baculovirus expressed human Retinoic acid receptor gamma | ChEMBL. | 10201840 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.