Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0143 | 0.1504 | 0.1485 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0022 | 0.0022 |
Echinococcus granulosus | insulin receptor | 0.0143 | 0.1504 | 0.1485 |
Schistosoma mansoni | tyrosine kinase | 0.0143 | 0.1504 | 0.1504 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0591 | 1 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0591 | 1 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0143 | 0.1504 | 0.1485 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0591 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0143 | 0.1504 | 0.1504 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0143 | 0.1504 | 0.1485 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0591 | 1 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0591 | 1 | 0.5 |
Onchocerca volvulus | 0.0591 | 1 | 0.5 | |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0591 | 1 | 1 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0591 | 1 | 0.5 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0591 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0591 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0591 | 1 | 1 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0591 | 1 | 1 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0591 | 1 | 1 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0591 | 1 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0143 | 0.1504 | 0.1485 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0591 | 1 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0079 | 0.0289 | 0.0268 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0143 | 0.1504 | 0.1485 |
Trichomonas vaginalis | cdc25c, putative | 0.0591 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.9124 | 0.9122 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0267 | 0.0246 |
Trichomonas vaginalis | cdc25b, putative | 0.0591 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0022 | 0.0022 |
Onchocerca volvulus | 0.0591 | 1 | 0.5 | |
Onchocerca volvulus | 0.0591 | 1 | 0.5 | |
Onchocerca volvulus | 0.0591 | 1 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0022 | 0.0022 |
Trichomonas vaginalis | cdc25b, putative | 0.0591 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.9124 | 0.9122 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K inact (binding) | = 0.25 min-1 | Inactivation constant of compound was determined by using bovine dopamine beta-hydroxylase | ChEMBL. | 2704022 |
K inact (binding) | = 0.25 min-1 | Inactivation constant of compound was determined by using bovine dopamine beta-hydroxylase | ChEMBL. | 2704022 |
Ki (binding) | = 3.2 mM | Compound was evaluated for the ability to bind to dopamine beta-hydroxylase of bovine | ChEMBL. | 2704022 |
Ki (binding) | = 3.2 mM | Compound was evaluated for the ability to bind to dopamine beta-hydroxylase of bovine | ChEMBL. | 2704022 |
Partition ratio (binding) | = 35 | Partition ratio was determined by quantitating amount of compound consumed after complete inactivation of a known amount of dopamine beta-hydroxylase. | ChEMBL. | 2704022 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.