Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0293 | 0.035 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.035 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0293 | 0.035 | 0.035 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0293 | 0.035 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.035 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0293 | 0.035 | 0.035 |
Schistosoma mansoni | coup transcription factor | 0.0293 | 0.035 | 0.035 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0293 | 0.035 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0293 | 0.035 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0293 | 0.035 | 0.035 |
Schistosoma mansoni | thyroid hormone receptor | 0.0293 | 0.035 | 0.035 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0293 | 0.035 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0293 | 0.035 | 0.0364 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0293 | 0.035 | 0.5 |
Onchocerca volvulus | 0.0293 | 0.035 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.035 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0293 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0293 | 0.035 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0293 | 0.035 | 0.035 |
Brugia malayi | nuclear hormone receptor | 0.0293 | 0.035 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0293 | 0.035 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0293 | 0.035 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0293 | 0.035 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0293 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0293 | 0.035 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0293 | 0.035 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0293 | 0.035 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.035 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0293 | 0.035 | 0.035 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0293 | 0.035 | 0.035 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0293 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0293 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0293 | 0.035 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0293 | 0.035 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.4106 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0293 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0293 | 0.035 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0293 | 0.035 | 0.035 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0293 | 0.035 | 0.035 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0293 | 0.035 | 0.035 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0293 | 0.035 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0293 | 0.035 | 0.035 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0293 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0293 | 0.035 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0293 | 0.035 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0293 | 0.035 | 0.035 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0293 | 0.035 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0293 | 0.035 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.035 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0293 | 0.035 | 0.0364 |
Schistosoma mansoni | nuclear hormone receptor | 0.0293 | 0.035 | 0.035 |
Brugia malayi | steroid hormone receptor | 0.0293 | 0.035 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0293 | 0.035 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.035 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0293 | 0.035 | 0.0364 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0293 | 0.035 | 0.0364 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.3951 | 0.9608 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.035 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0293 | 0.035 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0293 | 0.035 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0293 | 0.035 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0293 | 0.035 | 0.0364 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0293 | 0.035 | 0.035 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0293 | 0.035 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0293 | 0.035 | 0.035 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0293 | 0.035 | 0.035 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0293 | 0.035 | 0.0364 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0293 | 0.035 | 0.035 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0293 | 0.035 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.035 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0293 | 0.035 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 31000 nM | Tested in vitro for the inhibition of ADP-induced aggregation of human blood platelets | ChEMBL. | No reference |
IC50 (functional) | = 31000 nM | Tested in vitro for the inhibition of ADP-induced aggregation of human blood platelets | ChEMBL. | No reference |
IC50 (binding) | = 48000 nM | Inhibition of fibrinogen binding to immobilized human glycoprotein alpha IIb beta3 integrin | ChEMBL. | No reference |
IC50 (binding) | = 48000 nM | Inhibition of fibrinogen binding to immobilized human glycoprotein alpha IIb beta3 integrin | ChEMBL. | No reference |
Inhibition (functional) | 0 % | Ex vivo platelet aggregation of compound was measured in guinea pig up to 5 hr administered intraduodenally; NT=Not tested | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.