Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | < 25 mg kg-1 | Minimal motor impairment activity by Rotorod test in mice following i.p. administration. | ChEMBL. | 9438023 |
ED50 (functional) | < 25 mg kg-1 | Minimal motor impairment activity by Rotorod test in rat following p.o. administration. | ChEMBL. | 9438023 |
ED50 (functional) | < 25 mg kg-1 | Minimal motor impairment activity by Rotorod test in mice following i.p. administration. | ChEMBL. | 9438023 |
Protection (functional) | = 100 % | Anticonvulsant activity of the compound was measured by maximal electroshock seizure test in mice by ip administration at 30 mg/kg | ChEMBL. | 9438023 |
Protection (functional) | = 100 % | Anticonvulsant activity of the compound was measured by maximal electroshock seizure test in rat by po administration at 30 mg/kg | ChEMBL. | 9438023 |
Protection (functional) | = 100 % | Anticonvulsant activity of the compound was measured by maximal electroshock seizure test in mice by ip administration at 30 mg/kg | ChEMBL. | 9438023 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.