Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0154 | 0.0418 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0163 | 0.0454 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0116 | 0.0257 | 0.0171 |
Mycobacterium ulcerans | thymidylate synthase | 0.0116 | 0.0257 | 0.5 |
Brugia malayi | hypothetical protein | 0.0075 | 0.0088 | 0.0088 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0154 | 0.0418 | 0.0333 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0116 | 0.0257 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0163 | 0.0454 | 0.1198 |
Onchocerca volvulus | 0.0116 | 0.0257 | 0.5 | |
Echinococcus granulosus | presenilin | 0.0154 | 0.0418 | 0.0333 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0145 | 0.0379 | 0.0379 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0145 | 0.0379 | 0.0379 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0953 | 0.3759 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0116 | 0.0257 | 0.0171 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0154 | 0.0418 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0116 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0088 | 0.0088 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0154 | 0.0418 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0163 | 0.0454 | 0.0108 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0154 | 0.0418 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0163 | 0.0454 | 0.5 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.2447 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0953 | 0.3759 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0163 | 0.0454 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.2447 | 1 | 1 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0154 | 0.0418 | 0.1102 |
Brugia malayi | Presenilin family protein | 0.0154 | 0.0418 | 0.0418 |
Brugia malayi | hypothetical protein | 0.0055 | 0.0004 | 0.0004 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0145 | 0.0379 | 0.0293 |
Trichomonas vaginalis | Nicastrin precursor, putative | 0.0075 | 0.0088 | 0.203 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.2447 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0116 | 0.0257 | 0.0171 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0145 | 0.0379 | 0.0293 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0116 | 0.0257 | 1 |
Brugia malayi | hypothetical protein | 0.0075 | 0.0088 | 0.0088 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.2447 | 1 | 1 |
Trichomonas vaginalis | Nicastrin precursor, putative | 0.0075 | 0.0088 | 0.203 |
Echinococcus multilocularis | presenilin | 0.0154 | 0.0418 | 0.0333 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0154 | 0.0418 | 0.1102 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0163 | 0.0454 | 1 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0953 | 0.3759 | 1 |
Brugia malayi | thymidylate synthase | 0.0116 | 0.0257 | 0.0257 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 100 mg kg-1 | Anticonvulsant activity in mouse maximal electroshock assay following i.p. administration. | ChEMBL. | 7205879 |
LD50 (ADMET) | > 100 mg kg-1 | Lethal dose was measured in mice after ip administration. | ChEMBL. | 7205879 |
ND50 (functional) | > 100 mg kg-1 | Dose causing a neurological deficit in 50% of mice after ip administration. | ChEMBL. | 7205879 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.