Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1146 | 0.3344 | 0.3338 |
Schistosoma mansoni | tyrosine kinase | 0.0146 | 0.0192 | 0.0184 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0152 | 0.0211 | 0.0203 |
Schistosoma mansoni | tyrosine kinase | 0.0275 | 0.0598 | 0.059 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0275 | 0.0598 | 0.059 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0152 | 0.0211 | 0.0203 |
Schistosoma mansoni | tyrosine kinase | 0.0146 | 0.0192 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0211 | 0.0203 |
Schistosoma mansoni | tyrosine kinase | 0.0146 | 0.0192 | 0.0184 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0275 | 0.0598 | 0.059 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.2241 | 0.6798 | 0.6795 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0275 | 0.0598 | 0.0598 |
Schistosoma mansoni | tyrosine kinase | 0.0148 | 0.0197 | 0.0189 |
Schistosoma mansoni | tyrosine kinase | 0.0148 | 0.0197 | 0.0189 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0148 | 0.0197 | 0.0189 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.2241 | 0.6798 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0152 | 0.0211 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.3257 | 1 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.3257 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2241 | 0.6798 | 0.6795 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0148 | 0.0197 | 0.0197 |
Leishmania major | C-8 sterol isomerase-like protein | 0.2241 | 0.6798 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0211 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0211 | 0.0203 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0152 | 0.0211 | 0.0203 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0275 | 0.0598 | 0.059 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.3257 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0152 | 0.0211 | 0.0203 |
Echinococcus multilocularis | insulin receptor | 0.0088 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | serotonin transporter b | 0.0152 | 0.0211 | 0.0203 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.3257 | 1 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.3257 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0152 | 0.0211 | 0.0203 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0088 | 0.0009 | 0.0009 |
Echinococcus granulosus | serotonin transporter | 0.0152 | 0.0211 | 0.0203 |
Echinococcus multilocularis | serotonin transporter | 0.0152 | 0.0211 | 0.0211 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0148 | 0.0197 | 0.0189 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.2241 | 0.6798 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Aspirin formed (ADMET) | = 30 % | Percentage of aspirin formed during hydrolysis of the compound in 10% human plasma at pH 7.4 at 37 degrees celsius | ChEMBL. | 2918521 |
Aspirin formed (ADMET) | = 30 % | Percentage of aspirin formed during hydrolysis of the compound in 10% human plasma at pH 7.4 at 37 degrees celsius | ChEMBL. | 2918521 |
Aspirin formed (ADMET) | = 31 % | Percentage of aspirin formed during hydrolysis of the compound in undiluted human plasma at pH 7.4 at 37 degrees celsius | ChEMBL. | 2918521 |
Aspirin formed (ADMET) | = 31 % | Percentage of aspirin formed during hydrolysis of the compound in undiluted human plasma at pH 7.4 at 37 degrees celsius | ChEMBL. | 2918521 |
K obs (ADMET) | = 2070 min-1 | Observed pseudo-first order rate constant | ChEMBL. | 2918521 |
K1 (ADMET) | = 621 min-1 | Observed first order rate constant | ChEMBL. | 2918521 |
K2 (ADMET) | = 1450 min-1 | Observed second order rate constant | ChEMBL. | 2918521 |
logP (ADMET) | = 0.141 | Partition coefficient (logP) | ChEMBL. | 2918521 |
S | = 4.23 mg ml-1 | Solubility (21 degrees C) | ChEMBL. | 2918521 |
T1/2 (ADMET) | = 3.3 min | t1/2 in 10% human plasma | ChEMBL. | 2918521 |
T1/2 (ADMET) | = 3.3 min | t1/2 in 10% human plasma | ChEMBL. | 2918521 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.