Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Rhodanese-like domain containing protein | 0.0658 | 1 | 1 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0658 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0142 | 0.1324 | 0.1324 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0235 | 0.0216 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0658 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0142 | 0.1324 | 0.1324 |
Trichomonas vaginalis | cdc25b, putative | 0.0658 | 1 | 0.5 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0658 | 1 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0658 | 1 | 0.5 |
Onchocerca volvulus | 0.0658 | 1 | 0.5 | |
Trichomonas vaginalis | cdc25c, putative | 0.0658 | 1 | 0.5 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0658 | 1 | 1 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0658 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0142 | 0.1324 | 0.1307 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0142 | 0.1324 | 0.1307 |
Loa Loa (eye worm) | hypothetical protein | 0.0606 | 0.9135 | 0.9134 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0658 | 1 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0079 | 0.0255 | 0.0236 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0658 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0658 | 1 | 1 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0658 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0019 | 0.0019 |
Onchocerca volvulus | 0.0658 | 1 | 0.5 | |
Echinococcus granulosus | insulin receptor | 0.0142 | 0.1324 | 0.1307 |
Trichomonas vaginalis | cdc25b, putative | 0.0658 | 1 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0142 | 0.1324 | 0.1307 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0019 | 0.0019 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0019 | 0.0019 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0658 | 1 | 0.5 |
Onchocerca volvulus | 0.0658 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0606 | 0.9135 | 0.9134 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0142 | 0.1324 | 0.1307 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0658 | 1 | 0.5 |
Onchocerca volvulus | 0.0658 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0658 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0142 | 0.1324 | 0.1307 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CyD50 (ADMET) | = 100 ug ml-1 | Cytotoxic dose at which 50% growth of normal cells is inhibited | ChEMBL. | 1847431 |
CyD50 (functional) | = 100 ug ml-1 | Cytotoxic dose at which 50% growth of normal cells is inhibited against rhino virus infection. | ChEMBL. | 1847431 |
ED99 (functional) | = 6 ug ml-1 | Minimum drug concentration at which 99% of the polio virus is inhibited | ChEMBL. | 1847431 |
ED99 (functional) | < 1000 ug ml-1 | Minimum drug concentration at which 99% of the rhino virus is inhibited. | ChEMBL. | 1847431 |
mD (functional) | = 1.5 ug ml-1 | Minimal dose which produces titer reduction at 10 ug/mL (mD RF10e3) | ChEMBL. | 1847431 |
MNTD (functional) | = 100 ug ml-1 | Maximal non-toxic dose (MNTD) that shows antiviral activity. | ChEMBL. | 1847431 |
RF (functional) | = 0 | The ratio of the viral titer of the virus control (reduction factor) to the viral titer in the presence of the maximal non-toxic dose (RF MNTD) of the compound; Value expressed as 10e4.5 | ChEMBL. | 1847431 |
TI 99 (functional) | = 16.7 | Therapeutic Index measured as the ratio of CyD50(polio) / ED99(polio) values | ChEMBL. | 1847431 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.