Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | phospholipase A1, putative | 1.3514 | 1 | 1 |
Leishmania major | phospholipase A1, putative | 1.3514 | 1 | 1 |
Trypanosoma brucei | phospholipase A1, putative | 1.3514 | 1 | 1 |
Onchocerca volvulus | 1.3514 | 1 | 0.5 | |
Trypanosoma cruzi | phospholipase A1, putative | 1.3514 | 1 | 1 |
Onchocerca volvulus | 1.3514 | 1 | 0.5 | |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0165 | 0 | 0.5 |
Loa Loa (eye worm) | platelet-activating factor acetylhydrolase | 1.3514 | 1 | 1 |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.6197 | 0.4519 | 0.4519 |
Onchocerca volvulus | 1.3514 | 1 | 0.5 | |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.6197 | 0.4519 | 0.4519 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Saluretic potency (ADMET) | < 0.2 u equiv | Saluretic property (excretion of Na+ in rat after PO dosing) | ChEMBL. | 7097728 |
Saluretic potency (ADMET) | < 0.3 u equiv | Saluretic property (excretion of Na+ in rat) | ChEMBL. | 7097728 |
Saluretic potency (ADMET) | = 250 u equiv min-1 | Saluretic property was estimated by the excretion of Na+ in dog administered intravenously; microequiv of Na+/min at 5 mg/kg iv stat, 250-399 | ChEMBL. | 7097728 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.