Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | choline kinase alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | choline/ethanolamine kinase | choline kinase alpha | 457 aa | 474 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.2772 | 0.2772 |
Echinococcus granulosus | choline:ethanolamine kinase | 0.0049 | 0.6928 | 0.6928 |
Brugia malayi | Choline/ethanolamine kinase family protein | 0.0049 | 0.6928 | 0.6838 |
Onchocerca volvulus | 0.0028 | 0.2772 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2674 | 0.2674 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.2772 | 0.2772 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.2772 | 0.2772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0065 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.2772 | 0.2561 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.2772 | 0.2561 |
Echinococcus multilocularis | lamin | 0.0028 | 0.2772 | 0.2772 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0285 | 0.0285 |
Echinococcus multilocularis | choline:ethanolamine kinase | 0.0049 | 0.6928 | 0.6928 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.2772 | 0.2772 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0049 | 0.6928 | 0.6928 |
Echinococcus multilocularis | musashi | 0.0028 | 0.2772 | 0.2772 |
Echinococcus granulosus | lamin | 0.0028 | 0.2772 | 0.2772 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.2772 | 0.2772 |
Plasmodium vivax | choline kinase, putative | 0.0049 | 0.6928 | 0.5 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0049 | 0.6928 | 0.5 |
Onchocerca volvulus | 0.0028 | 0.2772 | 0.5 | |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.2772 | 0.2772 |
Plasmodium falciparum | choline kinase | 0.0049 | 0.6928 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.55 uM | Compound was tested in vitro for antiproliferative activity against human HT-29 cell line | ChEMBL. | 10782682 |
IC50 (functional) | = 0.55 uM | Compound was tested in vitro for antiproliferative activity against human HT-29 cell line | ChEMBL. | 10782682 |
IC50 (binding) | = 17 uM | Compound was tested ex vivo for inhibition against purified choline kinase obtained from yeast | ChEMBL. | 10782682 |
IC50 (binding) | = 17 uM | Compound was tested ex vivo for inhibition against purified choline kinase obtained from yeast | ChEMBL. | 10782682 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 10782682 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.