Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0034 | 0.8263 | 0.7417 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0037 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.5066 | 0.8879 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0016 | 0 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0028 | 0.5705 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0028 | 0.5705 | 0.3615 |
Echinococcus granulosus | glutamate receptor 2 | 0.0034 | 0.8263 | 0.7417 |
Leishmania major | cytochrome p450-like protein | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0034 | 0.8263 | 0.7417 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0027 | 0.5011 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0034 | 0.8263 | 0.7417 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0028 | 0.5705 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0034 | 0.8263 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0034 | 0.8263 | 0.7417 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0037 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0034 | 0.8263 | 0.7417 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.5066 | 0.8879 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0027 | 0.5011 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0027 | 0.5011 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0034 | 0.8263 | 0.7417 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0034 | 0.8263 | 0.7417 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0028 | 0.5705 | 0.3615 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0028 | 0.5705 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0028 | 0.5705 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0027 | 0.5011 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0027 | 0.5011 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0034 | 0.8263 | 0.7417 |
Chlamydia trachomatis | glutamine binding protein | 0.0027 | 0.5011 | 0.5 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0028 | 0.5705 | 0.3615 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0034 | 0.8263 | 0.7417 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (binding) | = 40 ug ml-1 | Inhibitory dose against oncornaviral DNA polymerase activity of moloney murine leukemia virus | ChEMBL. | 6157024 |
ID50 (binding) | = 40 ug ml-1 | Inhibitory dose against oncornaviral DNA polymerase activity of moloney murine leukemia virus | ChEMBL. | 6157024 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.