Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 5A, cGMP-specific | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | caspase 3 | 0.0217 | 0.4177 | 0.1294 |
Plasmodium vivax | metacaspase 1, putative | 0.0189 | 0.3311 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0404 | 0.9924 | 0.9924 |
Plasmodium falciparum | metacaspase 1 | 0.0189 | 0.3311 | 0.5 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0094 | 0.0387 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.41 | 0.3894 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0189 | 0.3311 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0189 | 0.3311 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0187 | 0.3243 | 0.2995 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.41 | 0.41 |
Trypanosoma brucei | metacaspase MCA2 | 0.0189 | 0.3311 | 0.5 |
Trypanosoma brucei | Metacaspase-4 | 0.0189 | 0.3311 | 0.5 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0215 | 0.41 | 0.118 |
Trypanosoma cruzi | metacaspase, putative | 0.0189 | 0.3311 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0189 | 0.3311 | 0.5 |
Echinococcus granulosus | caspase 2 | 0.0404 | 0.9924 | 0.9886 |
Plasmodium falciparum | metacaspase-like protein | 0.0189 | 0.3311 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0171 | 0.2767 | 0.2496 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0189 | 0.3311 | 0.5 |
Echinococcus granulosus | caspase | 0.0406 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0189 | 0.3311 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0404 | 0.9924 | 1 |
Brugia malayi | hypothetical protein | 0.0215 | 0.41 | 0.3894 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0189 | 0.3311 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0189 | 0.3311 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.011 | 0.0863 | 0.0499 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0189 | 0.3311 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0189 | 0.3311 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0189 | 0.3311 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0281 | 0.6142 | 0.4232 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0094 | 0.0387 | 0.5 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0189 | 0.3311 | 0.3066 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0189 | 0.3311 | 0.5 |
Echinococcus granulosus | caspase 3 | 0.0217 | 0.4177 | 0.1294 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0189 | 0.3311 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0189 | 0.3311 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0189 | 0.3311 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0406 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0171 | 0.2767 | 0.2102 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0189 | 0.3311 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.9924 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0189 | 0.3311 | 0.5 |
Echinococcus multilocularis | caspase | 0.0406 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0189 | 0.3311 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0189 | 0.3311 | 0.5 |
Trypanosoma brucei | metacaspase 5, putative | 0.0189 | 0.3311 | 0.5 |
Trypanosoma brucei | metacaspase MCA3 | 0.0189 | 0.3311 | 0.5 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0215 | 0.41 | 0.118 |
Trypanosoma brucei | metacaspase | 0.0189 | 0.3311 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0189 | 0.3311 | 0.5 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0406 | 1 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0189 | 0.3311 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0187 | 0.3243 | 0.2995 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0189 | 0.3311 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.3311 | 0.3066 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0281 | 0.6142 | 0.4232 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0406 | 1 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0094 | 0.0387 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.0863 | 0.0863 |
Brugia malayi | Cell death protein 3 precursor | 0.0404 | 0.9924 | 1 |
Leishmania major | metacaspase, putative | 0.0189 | 0.3311 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0189 | 0.3311 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0171 | 0.2767 | 0.2102 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0189 | 0.3311 | 0.3311 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0189 | 0.3311 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.0404 | 0.9924 | 0.9886 |
Onchocerca volvulus | 0.0215 | 0.41 | 0.3573 | |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0189 | 0.3311 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.