Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 4-aminobutyrate aminotransferase | Starlite/ChEMBL | References |
Sus scrofa | Gamma-amino-N-butyrate transaminase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Candida albicans | one of two potential aminotransferase genes | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Candida albicans | one of two potential aminotransferase genes similar to S. cerevisiae UGA1 (YGR019W) gamma-aminobutyrate (GABA) transaminase | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Mycobacterium ulcerans | L-lysine aminotransferase | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Candida albicans | one of two potential aminotransferase genes | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | 0.0586 | 0.5 | 0.5 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0586 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 9 uM | Compound was tested for the inhibitory effect against Gamma-amino-N-butyrate transaminase from bacteria | ChEMBL. | 3701787 |
Ki (binding) | = 9 uM | Compound was tested for the inhibitory effect against Gamma-amino-N-butyrate transaminase from bacteria | ChEMBL. | 3701787 |
Ki (binding) | = 19 uM | Compound was tested for the inhibitory effect against Gamma-amino-N-butyrate transaminase from pig brain | ChEMBL. | 3701787 |
Ki (binding) | = 19 uM | Compound was tested for the inhibitory effect against Gamma-amino-N-butyrate transaminase from pig brain | ChEMBL. | 3701787 |
Km (binding) | = 130 uM | Compound was tested for the inhibitory effect against Gamma-amino-N-butyrate transaminase from pig brain, activity expressed as Km | ChEMBL. | 3701787 |
Km (binding) | = 130 uM | Compound was tested for the inhibitory effect against Gamma-amino-N-butyrate transaminase from pig brain, activity expressed as Km | ChEMBL. | 3701787 |
Km (binding) | = 140 uM | Compound was tested for the inhibitory effect against Gamma-amino-N-butyrate transaminase from pig brain, activity expressed as Km | ChEMBL. | 3701787 |
Km (binding) | = 140 uM | Compound was tested for the inhibitory effect against Gamma-amino-N-butyrate transaminase from pig brain, activity expressed as Km | ChEMBL. | 3701787 |
Vmax (binding) | = 0.088 uM min-1mg-1 | Compound was tested for the inhibitory effect against Gamma-amino-N-butyrate transaminase from pig brain, activity expressed as Vmax | ChEMBL. | 3701787 |
Vmax (binding) | = 0.08800000000000002 uM min-1mg-1 | Compound was tested for the inhibitory effect against Gamma-amino-N-butyrate transaminase from pig brain, activity expressed as Vmax | ChEMBL. | 3701787 |
Vmax (binding) | = 0.36 uM min-1mg-1 | Compound was tested for the inhibitory effect against Gamma-amino-N-butyrate transaminase from pig brain, activity expressed as Vmax | ChEMBL. | 3701787 |
Vmax (binding) | = 0.36 uM min-1mg-1 | Compound was tested for the inhibitory effect against Gamma-amino-N-butyrate transaminase from pig brain, activity expressed as Vmax | ChEMBL. | 3701787 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.