Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0166 | 0.0931 | 0.0515 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0194 | 0.1182 | 0.1182 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0194 | 0.1182 | 0.1182 |
Brugia malayi | Carboxylesterase family protein | 0.0194 | 0.1182 | 0.1182 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0194 | 0.1182 | 0.0778 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0325 | 0.2401 | 1 |
Echinococcus multilocularis | neuroligin | 0.0194 | 0.1182 | 0.0778 |
Brugia malayi | Carboxylesterase family protein | 0.1146 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0194 | 0.1182 | 0.1182 |
Loa Loa (eye worm) | carboxylesterase | 0.0194 | 0.1182 | 0.0578 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0325 | 0.2401 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0194 | 0.1182 | 0.0778 |
Loa Loa (eye worm) | carboxylesterase | 0.1146 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0135 | 0.0642 | 0.0642 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1182 | 0.0578 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0123 | 0.0524 | 0.0524 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1146 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.0931 | 0.0309 |
Echinococcus granulosus | acetylcholinesterase | 0.1146 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1182 | 0.0578 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0154 | 0.0813 | 0.0813 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0194 | 0.1182 | 0.0778 |
Brugia malayi | Carboxylesterase family protein | 0.0194 | 0.1182 | 0.1182 |
Loa Loa (eye worm) | hypothetical protein | 0.1146 | 1 | 1 |
Onchocerca volvulus | 0.0194 | 0.1182 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0194 | 0.1182 | 0.1182 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0302 | 0.2189 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1146 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0194 | 0.1182 | 0.1182 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0113 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1182 | 0.0578 |
Onchocerca volvulus | 0.0194 | 0.1182 | 0.5 | |
Onchocerca volvulus | 0.0194 | 0.1182 | 0.5 | |
Schistosoma mansoni | acetylcholinesterase | 0.0194 | 0.1182 | 0.1182 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0194 | 0.1182 | 0.1182 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0166 | 0.0931 | 0.0515 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0194 | 0.1182 | 0.0778 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1182 | 0.0578 |
Echinococcus granulosus | neuroligin | 0.0194 | 0.1182 | 0.0778 |
Echinococcus granulosus | acetylcholinesterase | 0.1146 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0194 | 0.1182 | 0.1182 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0194 | 0.1182 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1182 | 0.0578 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0194 | 0.1182 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0194 | 0.1182 | 0.1182 |
Loa Loa (eye worm) | carboxylesterase | 0.0194 | 0.1182 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.1146 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1182 | 0.0578 |
Echinococcus multilocularis | acetylcholinesterase | 0.1146 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1146 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1146 | 1 | 1 |
Onchocerca volvulus | 0.0194 | 0.1182 | 0.5 | |
Onchocerca volvulus | 0.0194 | 0.1182 | 0.5 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0194 | 0.1182 | 0.0778 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1182 | 0.0578 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0194 | 0.1182 | 0.0778 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1146 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0194 | 0.1182 | 0.1182 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease in blood pressure (functional) | = 12 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 6-12 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
Decrease in blood pressure (functional) | = 12 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 12-18 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
Decrease in blood pressure (functional) | = 12 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 6-12 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
Decrease in blood pressure (functional) | = 12 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 12-18 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
Decrease in blood pressure (functional) | = 13 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 0-6 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
Decrease in blood pressure (functional) | = 13 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 0-6 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
IC50 (functional) | > 30 uM | Concentration required to cause 50% relaxation of maximal contraction in circumferential rabbit aorta strips in response to KCl (100 mM) | ChEMBL. | 1311765 |
logP (ADMET) | = 1 | Partition coefficient (logP) | ChEMBL. | 1311765 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.