Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.709 | 0.94 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.4351 | 0.5146 | 1 |
Brugia malayi | nuclear hormone receptor | 0.709 | 0.94 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.4351 | 0.5146 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.3965 | 0.4546 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Duration (functional) | = 10 min | The time to 50% recovery of the angiotensin I response was measured after po administration of the compound at 1.5 mg/kg; 10-60 | ChEMBL. | 3009814 |
Duration (functional) | = 10 min | The time to 50% recovery of the angiotensin I response was measured after po administration of the compound at 1.5 mg/kg; 10-60 | ChEMBL. | 3009814 |
I50 (binding) | > 100 uM | In vitro inhibition of Angiotensin I converting enzyme activity in rabbit lung | ChEMBL. | 3009814 |
I50 (binding) | > 100 uM | In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lung | ChEMBL. | 3009814 |
IC50 (binding) | > 100 uM | In vitro inhibition of Angiotensin I converting enzyme activity in rabbit lung | ChEMBL. | 3009814 |
IC50 (binding) | > 100 uM | In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lung | ChEMBL. | 3009814 |
Inhibition (functional) | = 14 % | Percentage inactivation of the angiotensin I induced vasopressor response in normotensive conscious rats after po administration at dose 1.5 mg/kg; 14-16 | ChEMBL. | 3009814 |
Inhibition (functional) | = 14 % | Percentage inactivation of the angiotensin I induced vasopressor response in normotensive conscious rats after po administration at dose 1.5 mg/kg; 14-16 | ChEMBL. | 3009814 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.