Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrix metalloproteinase | 0.0183 | 0.0043 | 0.057 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3716 | 0.3725 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0405 | 0.0275 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0405 | 0.0275 | 0.3624 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.9738 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0043 | 0.057 |
Onchocerca volvulus | 0.0259 | 0.0123 | 0.3431 | |
Loa Loa (eye worm) | hypothetical protein | 0.087 | 0.0759 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0223 | 0.0085 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0043 | 0.057 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.3716 | 0.3725 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0223 | 0.0085 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0043 | 0.057 |
Schistosoma mansoni | hypothetical protein | 0.0259 | 0.0123 | 0.4319 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0195 | 0.0057 | 0.1988 |
Echinococcus granulosus | adam 17 protease | 0.0455 | 0.0327 | 0.5624 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0664 | 0.0545 | 1 |
Trypanosoma brucei | Peptide deformylase 2 | 0.3716 | 0.3725 | 0.5 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.026 | 0.0124 | 0.1531 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0187 | 0.0047 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0047 | 0.0624 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0664 | 0.0545 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.0085 | 0.1117 |
Echinococcus multilocularis | adam 17 protease | 0.0414 | 0.0284 | 0.476 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.3716 | 0.3725 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0187 | 0.0047 | 0.1662 |
Toxoplasma gondii | hypothetical protein | 0.9738 | 1 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0223 | 0.0085 | 0.1537 |
Brugia malayi | Peptidase family M13 containing protein | 0.0187 | 0.0047 | 0.0151 |
Brugia malayi | Matrixin family protein | 0.0442 | 0.0313 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0047 | 0.0624 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0047 | 0.0624 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0405 | 0.0275 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0442 | 0.0313 | 0.4125 |
Mycobacterium ulcerans | peptide deformylase | 0.9738 | 1 | 1 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0195 | 0.0057 | 0.0493 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0223 | 0.0085 | 0.0038 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0414 | 0.0284 | 1 |
Brugia malayi | Hemopexin family protein | 0.0259 | 0.0123 | 0.2947 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0195 | 0.0057 | 0.0186 |
Plasmodium falciparum | peptide deformylase | 0.9738 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.9738 | 1 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.9738 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.9738 | 1 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.9738 | 1 | 0.5 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.026 | 0.0124 | 0.1531 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0195 | 0.0057 | 0.0186 |
Mycobacterium tuberculosis | Possible exported protein | 0.0997 | 0.0892 | 0.0849 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0183 | 0.0043 | 0.1519 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3716 | 0.3725 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3716 | 0.3725 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3716 | 0.3725 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Conversion rate (functional) | = 6.1 % | Stereoselectivity in enzymic hydrolysis by mouse sarcoma S180 cells | ChEMBL. | No reference |
Conversion rate (functional) | = 6.1 % | Stereoselectivity in enzymic hydrolysis by mouse sarcoma S180 cells | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.