Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Acyl-CoA:cholesterol acyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | sterol O-acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Echinococcus granulosus | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Echinococcus multilocularis | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Schistosoma japonicum | ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | diacylglycerol O-acyltransferase 1 | Acyl-CoA:cholesterol acyltransferase | 305 aa | 278 aa | 21.9 % |
Neospora caninum | sterol O-acyltransferase, putative | Acyl-CoA:cholesterol acyltransferase | 305 aa | 258 aa | 20.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glutamate receptor 2 precursor | 0.0362 | 0.177 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0362 | 0.177 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0362 | 0.177 | 0.177 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0697 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0362 | 0.177 | 0.177 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0437 | 0.3633 | 0.3633 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0437 | 0.3633 | 0.3633 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0362 | 0.177 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0309 | 0.0472 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0437 | 0.3633 | 0.3633 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0316 | 0.0657 | 0.0657 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0678 | 0.9528 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0309 | 0.0472 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0309 | 0.0472 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0362 | 0.177 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0437 | 0.3633 | 0.3633 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0316 | 0.0657 | 0.0657 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0437 | 0.3633 | 0.3633 |
Echinococcus granulosus | glutamate receptor 2 | 0.0437 | 0.3633 | 0.3633 |
Chlamydia trachomatis | glutamine binding protein | 0.0309 | 0.0472 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0309 | 0.0472 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0457 | 0.4104 | 0.4104 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0362 | 0.177 | 0.177 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0437 | 0.3633 | 0.3633 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0309 | 0.0472 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0437 | 0.3633 | 0.3633 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0437 | 0.3633 | 0.3633 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0437 | 0.3633 | 0.3633 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.94 uM | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in liver microsomes isolated from cholesterol-fed rabbits | ChEMBL. | 8145231 |
IC50 (binding) | = 0.94 uM | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in liver microsomes isolated from cholesterol-fed rabbits | ChEMBL. | 8145231 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.