Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0675 | 0.0546 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0048 | 0.0632 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3803 | 0.3729 | 0.5 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0264 | 0.0128 | 0.1643 |
Brugia malayi | Hemopexin family protein | 0.0263 | 0.0127 | 0.3014 |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0048 | 0.0094 |
Echinococcus granulosus | adam 17 protease | 0.0463 | 0.033 | 0.5681 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0199 | 0.0061 | 0.0583 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0089 | 0.1175 |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0048 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0045 | 0.0599 |
Mycobacterium ulcerans | hydrolase | 0.0226 | 0.0089 | 0.0044 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3803 | 0.3729 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0412 | 0.0278 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.3803 | 0.3729 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0045 | 0.0599 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0183 | 0.0045 | 0.1429 |
Schistosoma mansoni | hypothetical protein | 0.0263 | 0.0127 | 0.4319 |
Loa Loa (eye worm) | hypothetical protein | 0.0884 | 0.0758 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.9966 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0412 | 0.0278 | 0.3666 |
Mycobacterium tuberculosis | Possible exported protein | 0.1491 | 0.1376 | 0.1337 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0264 | 0.0128 | 0.1643 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0199 | 0.0061 | 0.1988 |
Trypanosoma brucei | Peptide deformylase 2 | 0.3803 | 0.3729 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3803 | 0.3729 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.3803 | 0.3729 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0186 | 0.0048 | 0.1519 |
Toxoplasma gondii | hypothetical protein | 0.9966 | 1 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.9966 | 1 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.9966 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.9966 | 1 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0226 | 0.0089 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0045 | 0.0599 |
Echinococcus multilocularis | adam 17 protease | 0.0421 | 0.0287 | 0.4829 |
Treponema pallidum | polypeptide deformylase (def) | 0.9966 | 1 | 0.5 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0199 | 0.0061 | 0.0315 |
Brugia malayi | Matrixin family protein | 0.0449 | 0.0316 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0412 | 0.0278 | 1 |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0048 | 0.0094 |
Loa Loa (eye worm) | matrixin family protein | 0.0449 | 0.0316 | 0.4164 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0186 | 0.0048 | 0.0632 |
Plasmodium falciparum | peptide deformylase | 0.9966 | 1 | 0.5 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0199 | 0.0061 | 0.0315 |
Onchocerca volvulus | 0.0263 | 0.0127 | 0.3431 | |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0421 | 0.0287 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0048 | 0.0632 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3803 | 0.3729 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0226 | 0.0089 | 0.0044 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0675 | 0.0546 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0048 | 0.0632 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0226 | 0.0089 | 0.1617 |
Mycobacterium ulcerans | peptide deformylase | 0.9966 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0048 | 0.0094 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 33.43 uM | Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) | ChEMBL. | 12086483 |
Activity (binding) | = 33.43 uM | Inhibition of HIV-1 reverse transcriptase. | ChEMBL. | 12723956 |
Activity (binding) | = 33.43 uM | Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) | ChEMBL. | 12086483 |
Activity (binding) | = 33.43 uM | Inhibition of HIV-1 reverse transcriptase. | ChEMBL. | 12723956 |
IC50 (binding) | = 4.476 | Inhibition of HIV1 reverse transcriptase | ChEMBL. | 18760864 |
IC50 (functional) | = 33.43 uM | Concentration required for 50% protection of MT-4 cells against the cytopathic effect of HIV-1 | ChEMBL. | 7877144 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.