Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0125 | 0.21 | 0.6841 |
Onchocerca volvulus | 0.0125 | 0.21 | 1 | |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0125 | 0.21 | 0.1906 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0125 | 0.21 | 0.6841 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0125 | 0.21 | 0.6841 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0125 | 0.21 | 0.1906 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 0.151 | 0.4092 |
Schistosoma mansoni | adenosine deaminase | 0.0104 | 0.151 | 0.4673 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0125 | 0.21 | 0.6841 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0156 | 0.2959 | 0.2787 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.1315 | 0.3956 |
Onchocerca volvulus | 0.0067 | 0.0507 | 0.1438 | |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0156 | 0.2959 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0125 | 0.21 | 0.6841 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0125 | 0.21 | 0.1906 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 0.151 | 0.5104 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 0.151 | 0.5104 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0577 | 0.0346 |
Loa Loa (eye worm) | ACC-1 protein | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0507 | 0.0274 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0067 | 0.0507 | 0.0274 |
Schistosoma mansoni | nAChR subunit | 0.0125 | 0.21 | 0.6841 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0125 | 0.21 | 0.6841 |
Echinococcus multilocularis | nAChR subunit | 0.0125 | 0.21 | 0.6841 |
Onchocerca volvulus | 0.0125 | 0.21 | 1 | |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0104 | 0.151 | 0.6831 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0507 | 0.0274 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0125 | 0.21 | 0.6841 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0125 | 0.21 | 0.6841 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0104 | 0.151 | 0.1302 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0156 | 0.2959 | 1 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 0.151 | 0.4092 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0125 | 0.21 | 0.1906 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0411 | 1 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0125 | 0.21 | 0.1906 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0067 | 0.0507 | 0.0274 |
Onchocerca volvulus | 0.0125 | 0.21 | 1 | |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0067 | 0.0507 | 0.0983 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0125 | 0.21 | 0.6841 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0156 | 0.2959 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0507 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0507 | 0.0274 |
Onchocerca volvulus | 0.0125 | 0.21 | 1 | |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0125 | 0.21 | 0.6841 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0125 | 0.21 | 0.1906 |
Brugia malayi | Cation transporter family protein | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0125 | 0.21 | 0.6841 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0507 | 0.0274 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0125 | 0.21 | 0.1906 |
Schistosoma mansoni | nAChR subunit | 0.0125 | 0.21 | 0.6841 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0125 | 0.21 | 0.1906 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.1315 | 0.3956 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0125 | 0.21 | 0.6841 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0125 | 0.21 | 0.1906 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0125 | 0.21 | 0.1906 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0125 | 0.21 | 0.6841 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0507 | 0.0274 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0125 | 0.21 | 0.6841 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Schistosoma mansoni | adenosine deaminase-related | 0.0104 | 0.151 | 0.4673 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Echinococcus granulosus | nAChR subunit | 0.0125 | 0.21 | 0.6841 |
Schistosoma mansoni | nAChR subunit | 0.0125 | 0.21 | 0.6841 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0125 | 0.21 | 0.1906 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0125 | 0.21 | 0.6841 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0125 | 0.21 | 0.1906 |
Onchocerca volvulus | 0.0067 | 0.0507 | 0.1438 | |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Onchocerca volvulus | 0.0125 | 0.21 | 1 | |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0156 | 0.2959 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0507 | 0.0274 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.1315 | 0.3956 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0125 | 0.21 | 0.6841 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0577 | 0.0346 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0125 | 0.21 | 0.6841 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0507 | 0.0274 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0067 | 0.0507 | 0.0274 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0125 | 0.21 | 0.6841 |
Brugia malayi | Cation transporter family protein | 0.0125 | 0.21 | 0.1906 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0125 | 0.21 | 0.6841 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0156 | 0.2959 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0577 | 0.0346 |
Schistosoma mansoni | nAChR subunit | 0.0125 | 0.21 | 0.6841 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0125 | 0.21 | 0.6841 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0125 | 0.21 | 0.6841 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0067 | 0.0507 | 0.0274 |
Echinococcus granulosus | adenosine deaminase | 0.0104 | 0.151 | 0.4673 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0067 | 0.0507 | 0.0983 |
Onchocerca volvulus | Putative nachr subunit | 0.0125 | 0.21 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 0.2959 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0125 | 0.21 | 0.1906 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0125 | 0.21 | 0.6841 |
Brugia malayi | Adenosylhomocysteinase | 0.0156 | 0.2959 | 0.2787 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.151 | 0.1302 |
Echinococcus multilocularis | adenosine deaminase | 0.0104 | 0.151 | 0.4673 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0411 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0156 | 0.2959 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0125 | 0.21 | 0.6841 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.1315 | 0.3956 |
Brugia malayi | Cation transporter family protein | 0.0125 | 0.21 | 0.1906 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0156 | 0.2959 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | LGC-31 protein | 0.0125 | 0.21 | 0.1906 |
Treponema pallidum | adenosine deaminase | 0.0104 | 0.151 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Schistosoma mansoni | nAChR subunit | 0.0125 | 0.21 | 0.6841 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0125 | 0.21 | 0.6841 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0125 | 0.21 | 0.6841 |
Schistosoma mansoni | nAChR subunit | 0.0125 | 0.21 | 0.6841 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0067 | 0.0507 | 0.0983 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0125 | 0.21 | 0.6841 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0125 | 0.21 | 0.6841 |
Echinococcus multilocularis | nAChR subunit | 0.0067 | 0.0507 | 0.0983 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0156 | 0.2959 | 0.1707 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4449 | 0.4313 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0067 | 0.0507 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0125 | 0.21 | 0.6841 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0125 | 0.21 | 0.1906 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0156 | 0.2959 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Loa Loa (eye worm) | ACC-1 protein | 0.0125 | 0.21 | 0.1906 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0156 | 0.2959 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0507 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.21 | 0.1906 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0125 | 0.21 | 0.6841 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0125 | 0.21 | 0.6841 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0125 | 0.21 | 0.6841 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0577 | 0.0346 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0125 | 0.21 | 0.1906 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0156 | 0.2959 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0125 | 0.21 | 0.6841 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0156 | 0.2959 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0125 | 0.21 | 0.1906 |
Onchocerca volvulus | 0.0125 | 0.21 | 1 | |
Echinococcus granulosus | nAChR subunit | 0.0067 | 0.0507 | 0.0983 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 0.2959 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0411 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5 uM | Inhibitor constant against adenosine deaminase in 0.05 M sodium phosphate buffer at pH 7.0, was determined after heating to 100 degrees celsius | ChEMBL. | 7401106 |
Ki (binding) | = 520 uM | Inhibitory constant against adenosine deaminase in 0.05 M sodium phosphate buffer at pH 7.0, was determined before heating | ChEMBL. | 7401106 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.