Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0936 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0047 | 0.0064 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Echinococcus multilocularis | serotonin receptor | 0.0137 | 0.1071 | 0.1031 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0083 | 0.0463 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 21 | 0.0046 | 0.0044 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 39B | 0.0046 | 0.0044 | 0.0221 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1143 | 0.1143 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.1071 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0046 | 0.0044 | 0.0221 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0325 | 0.317 | 0.3139 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Brugia malayi | hypothetical protein | 0.0046 | 0.0044 | 0.0221 |
Loa Loa (eye worm) | TWK-28 protein | 0.0046 | 0.0044 | 0.0044 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0312 | 0.3021 | 0.299 |
Loa Loa (eye worm) | uncoordinated protein 58 | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Mycobacterium tuberculosis | Possible transmembrane cation transporter | 0.0046 | 0.0044 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 35 | 0.0046 | 0.0044 | 0.0221 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0715 | 0.7528 | 0.7517 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | TWK-7 protein | 0.0046 | 0.0044 | 0.0044 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0325 | 0.317 | 0.3139 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0046 | 0.0044 | 0.5 |
Brugia malayi | Twik (KCNK-like) family of potasium channels, alpha subunit 40 | 0.0046 | 0.0044 | 0.0221 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0083 | 0.0463 | 1 |
Mycobacterium ulcerans | transmembrane cation transporter | 0.0046 | 0.0044 | 0.5 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog | 0.0046 | 0.0044 | 0.0221 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0083 | 0.0463 | 1 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 45 | 0.0046 | 0.0044 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Onchocerca volvulus | Telomerase reverse transcriptase homolog | 0.0304 | 0.2937 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Echinococcus multilocularis | serotonin receptor | 0.0137 | 0.1071 | 0.1031 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 30. | 0.0046 | 0.0044 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog | 0.0046 | 0.0044 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 12 | 0.0046 | 0.0044 | 0.0221 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0083 | 0.0463 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0083 | 0.0463 | 1 |
Entamoeba histolytica | calcium-gated potassium channel protein, putative | 0.0046 | 0.0044 | 0.5 |
Mycobacterium ulcerans | ion transport protein | 0.0046 | 0.0044 | 0.5 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 28 | 0.0046 | 0.0044 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 5 | 0.0046 | 0.0044 | 0.0221 |
Schistosoma mansoni | hypothetical protein | 0.0936 | 1 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0137 | 0.1071 | 0.1031 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0051 | 0.0108 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0046 | 0.0044 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0891 | 0.949 | 0.9487 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0051 | 0.0108 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | S-phase kinase-associated protein 1A | 0.0046 | 0.0044 | 0.0044 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0046 | 0.0044 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0046 | 0.0044 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.4243 | 0.4243 |
Brugia malayi | Telomerase reverse transcriptase | 0.0221 | 0.2007 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0083 | 0.0463 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1412 | 0.1374 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | large conductance calcium-activated potassium channel alpha subunit ai | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0469 | 0.4781 | 0.4781 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 13 | 0.0046 | 0.0044 | 0.0221 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0083 | 0.0463 | 1 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 32 | 0.0046 | 0.0044 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 24 | 0.0046 | 0.0044 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0137 | 0.1071 | 0.1031 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0715 | 0.7528 | 0.7517 |
Schistosoma mansoni | serine-rich repeat protein | 0.0168 | 0.1412 | 0.1374 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Giardia lamblia | Telomerase catalytic subunit | 0.0083 | 0.0463 | 1 |
Schistosoma mansoni | amine GPCR | 0.0353 | 0.3481 | 0.3452 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 39A | 0.0046 | 0.0044 | 0.0221 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0046 | 0.0044 | 0.5 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0157 | 0.1292 | 0.1253 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 7 | 0.0046 | 0.0044 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Brugia malayi | Cache domain containing protein | 0.0144 | 0.1143 | 0.5697 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 17 | 0.0046 | 0.0044 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0044 | 0.0044 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 100 uM | Cytotoxic concentration required to reduce the viability of MT-4 cells | ChEMBL. | No reference |
CC50 (functional) | > 100 uM | Cytotoxic concentration required to reduce the viability of MT-4 cells | ChEMBL. | No reference |
CC50 (functional) | > 250 uM | The lowest concentration of compound producing overt cytotoxicity in virus-free vero cell cultures | ChEMBL. | No reference |
CC50 (functional) | > 250 uM | The lowest concentration of compound producing overt cytotoxicity in virus-free MRC-5 cell cultures | ChEMBL. | No reference |
CC50 (functional) | > 250 uM | The lowest concentration of compound producing overt cytotoxicity in virus-free MRC-5 cell cultures | ChEMBL. | No reference |
EC50 (functional) | > 100 uM | Concentration required to inhibit HIV-1-induced cytopathic effect by 50% in MT-4 cells | ChEMBL. | No reference |
EC50 (functional) | > 100 uM | Concentration required to inhibit p24 viral antigen production by 50% in C-8166 cells | ChEMBL. | No reference |
EC50 (functional) | > 100 uM | Concentration required to inhibit HIV-1-induced cytopathic effect by 50% in MT-4 cells | ChEMBL. | No reference |
EC50 (functional) | > 100 uM | Concentration required to inhibit p24 viral antigen production by 50% in C-8166 cells | ChEMBL. | No reference |
EC50 (functional) | > 250 uM | Anti-herpes virus activity of the compound was evaluated against Herpes simplex virus type 1 (HSV-1,strain HF) grown in Vero cells | ChEMBL. | No reference |
EC50 (functional) | > 250 uM | Anti-herpes virus activity of the compound was evaluated against Herpes simplex virus type 2 (HSV-2,strain G) grown in Vero cells | ChEMBL. | No reference |
EC50 (functional) | > 250 uM | Anti-herpes virus activity of the compound was evaluated against human cytomegalovirus (HCMV,strain AD-169) grown in MRC-5 cells | ChEMBL. | No reference |
EC50 (functional) | > 250 uM | Anti-herpes virus activity of the compound was evaluated against human cytomegalovirus (HCMV,strain AD-169) grown in MRC-5 cells | ChEMBL. | No reference |
ED50 (functional) | NA 0 uM | Anti HIV-l activity in infected MT-4 cells cultures; NA is NO Activity | ChEMBL. | 7525958 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.